Information acquisition method, information acquisition apparatus and disease diagnosis method
First Claim
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1. An information acquisition method for acquiring information on a target object, characterized in that it comprises the steps of:
- promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit; and
acquiring information on the mass of the flew target object using a time-of-flight secondary ion mass spectrometry.
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Abstract
An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.
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Citations
37 Claims
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1. An information acquisition method for acquiring information on a target object, characterized in that it comprises the steps of:
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promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit; and
acquiring information on the mass of the flew target object using a time-of-flight secondary ion mass spectrometry. - View Dependent Claims (2, 3, 4, 5, 6, 31, 32, 33, 34)
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7. An information acquisition apparatus for acquiring information on a target object using time-of-flight secondary ion mass spectrometry, characterized in that the apparatus comprises a means for contacting the target object with a substance for promoting ionization of the target object and a means for irradiating with an ion beam an area of contact between the target object and the substance for promoting ionization of the target object, wherein information on the mass of the target object at least one part of which object was ionized is acquired by the irradiation from the irradiating means.
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8. An information acquisition method for acquiring information on the mass of a target object using a time-of-flight mass spectrometer, characterized in that it comprises the steps of:
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applying a substance for promoting ionization of the target object;
ionizing the target object using a focused, pulsed and scannable primary beam to cause the target object to emit; and
acquiring information on the mass of the flew target object using a time-of-flight mass spectrometer. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. An information acquisition method for acquiring information on the mass of a constituent of a target object using a time-of-flight mass spectrometer to obtain information on a distribution of the constituent based on the acquired information, characterized in that the method comprises the steps of:
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preparing a sample comprising a constituent of tissue from a living organism as the target object;
conducting a treatment for promoting ionization of an ionic species deriving from the constituent;
irradiating the target object with a focused ion beam to cause the ionic species deriving from the constituent to emit; and
measuring an intensity of the flew ionic species using a time-of-flight mass spectrometer to obtain information on a distribution of the constituent based on the measured value. - View Dependent Claims (18, 19, 20, 21, 22, 23, 36)
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24. An information acquisition method for acquiring information on the mass of a constituent of a target object using a time-of-flight mass spectrometer to obtain information on a distribution of the constituent based on the acquired mass information, characterized in that the method comprises the steps of:
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preparing a sample comprising a constituent of tissue from a living organism;
contacting the sample with the surface of a substrate to transfer at least one part of the constituent to the substrate;
irradiating a focused ion beam onto the substrate to which at least one part of the constituent was transferred as the target object to cause an ionic species deriving from the constituent to emit; and
measuring an intensity of the flew ionic species using a time-of-flight mass spectrometer to obtain information on a distribution of the constituent based on the measured value. - View Dependent Claims (25, 26, 27, 28, 29, 35, 37)
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30. An information acquisition apparatus that acquires information on the mass of a constituent comprised of a target object using a time-of-flight mass spectrometer to obtain information on a distribution of the constituents based on the acquired mass information, characterized in that it comprises:
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a means for contacting the constituents with a substrate surface to transfer at least one part of the constituents to the substrate side;
a time-of-flight mass spectrometer that employs the substrate to which at least one part of the constituent was transferred as the target object, and irradiates the target object with a focused ion beam to cause ionic species deriving from the constituents to emit to measure intensities of the flew ionic species; and
a means for analyzing a measurement result for obtaining information on a distribution state of the constituents based on the measured value.
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Specification