FORMULATION FOR LIPOPHILIC AGENTS
First Claim
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1. A formulation, comprising a vitamin D compound;
- a non-ionic solubilizer selected from the group consisting of polyoxyalkylenes, polysorbate 20, fatty acid esters of glycerol, cyclodextrins, dextrans, and fatty alcohol ethers of oligoglucosides;
a lipophilic antioxidant selected from the group consisting of butylated hydroxytoluene (BHT), lipoic acid, lycopene, lutein, lycophyll, xanthophyll, carotene, zeaxanthin, vitamin E and esters thereof; and
an aqueous vehicle.
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Abstract
The invention relates to pharmaceutical formulations of lipophilic therapeutic agents in which such agents are solubilized in largely aqueous vehicles, and processes for preparing and using the same.
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Citations
45 Claims
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1. A formulation, comprising a vitamin D compound;
- a non-ionic solubilizer selected from the group consisting of polyoxyalkylenes, polysorbate 20, fatty acid esters of glycerol, cyclodextrins, dextrans, and fatty alcohol ethers of oligoglucosides;
a lipophilic antioxidant selected from the group consisting of butylated hydroxytoluene (BHT), lipoic acid, lycopene, lutein, lycophyll, xanthophyll, carotene, zeaxanthin, vitamin E and esters thereof; and
an aqueous vehicle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- a non-ionic solubilizer selected from the group consisting of polyoxyalkylenes, polysorbate 20, fatty acid esters of glycerol, cyclodextrins, dextrans, and fatty alcohol ethers of oligoglucosides;
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26. A parenteral formulation, comprising a vitamin D compound, 0.05 to 5% w/w of a non-ionic solublizer non-ionic selected from the group consisting of polyoxyalkylenes, polysorbate 20, fatty acid esters of glycerol, cyclodextrins, dextrans, and fatty alcohol ethers of oligoglucosides;
- and 20 to 2000 ppm of a lipophilic antioxidant selected from the group consisting of butylated hydroxytoluene (BHT), lipoic acid, lycopene, lutein, lycophyll, xanthophyll, carotene, zeaxanthin, vitamin E and esters thereof.
- View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
Specification