Biosensor membrane material
First Claim
1. A biocompatible multipolymer capable of forming a glucose-limiting permselective membrane, said multipolymer having at least one soft segment, wherein less than about 10% of total soft segment weight is made up of a hydrophilic soft segment.
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Abstract
Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
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Citations
41 Claims
- 1. A biocompatible multipolymer capable of forming a glucose-limiting permselective membrane, said multipolymer having at least one soft segment, wherein less than about 10% of total soft segment weight is made up of a hydrophilic soft segment.
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16. A permselective membrane, comprising:
a multipolymer having at least one soft segment, wherein less than 10% of total soft segment weight is made up of a hydrophilic soft segment. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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23. A biocompatible multipolymer, comprising:
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at least one hard segment;
about 55 to 90 wt % of soft segments, including;
about 5 to 25 wt %, of total soft segment weight, of an oxygen permeable soft segment, said oxygen permeable soft segment comprising at least one fluorine-containing soft segment;
less than about 25 wt %, of total soft segment weight, of a hydrophilic soft segment; and
about 50 to 90 wt %, of total soft segment weight, of a biostable, hydrophobic soft segment. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A biocompatible multipolymer, comprising:
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about 25-35 wt %, of total multipolymer weight, of hard segments;
about 25 to 40 wt %, of total multipolymer weight, of a first polycarbonate;
about 15 to 25 wt %, of total multipolymer weight, of polyethylene oxide or a second polycarbonate; and
about 15 to 25 wt %, of total multipolymer weight, of silicone, fluorocarbon, or fluorinated polyether. - View Dependent Claims (40)
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41. A drug delivery apparatus, comprising:
an insertable portion that is insertable in an animal body, wherein at least part of the insertable portion comprises a drug reservoir comprised of a multipolymer, said multipolymer comprising at least one hard segment;
about 55 to 90 wt % of soft segments, including about 5 to 25 wt %, of total soft segment weight, of an oxygen permeable soft segment, less than about 25 wt %, of total soft segment weight, of a hydrophilic soft segment, and about 50 to 90 wt %, of total soft segment weight, of a biostable, hydrophobic soft segment.
Specification