Intraocular lens measurement of blood glucose

• US 20060183986A1
• Filed: 02/11/2005
• Published: 08/17/2006
• Est. Priority Date: 02/11/2005
• Status: Abandoned Application

• Current Assignee: Fovioptics Incorporated
• Original Assignee: Fovioptics Incorporated
• Inventors: Smith, John L., Rice, Mark J.
• Application Number:
  US11/057,080
• Publication Number:
  US 20060183986A1
• Time in Patent Office: Days
• US Class Current: 600/319
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence

Abstract

One aspect of the invention provides a blood glucose monitoring system including a light source adapted to transmit light onto at least a portion of a retina of an eye of a subject; a sensor adapted to receive light from the retina; a data capture and analysis system adapted to calculate blood glucose concentration of the subject from the light received by the sensor; and support structure adapted to maintain positions of the light source and the sensor; wherein at least one of the light source and the sensor is further adapted to be implanted within the eye. Another aspect of the invention provides a method of determining blood glucose concentration of a subject including the steps of: transmitting light to a retina of an eye of the subject; receiving reflected light from the retina; and calculating blood glucose concentration from the reflected light, wherein one or both of the light source and sensor are disposed within the eye. The invention also provides a method of implanting a blood glucose monitor as well as a blood glucose monitor adapted to receive information from a sensor disposed within a subject'"'"'s eye.

Claims

1. A blood glucose monitoring system comprising:

a light source adapted to transmit light onto at least a portion of a retina of an eye of a subject;

a sensor adapted to receive light from the retina;

a data capture and analysis system adapted to calculate blood glucose concentration of the subject from the light received by the sensor;

and support structure adapted to maintain positions of the light source and the sensor;

wherein at least one of the light source and the sensor is further adapted to be implanted within the eye.

2. The system of claim 1 wherein the light source is further adapted to transmit light in wavelengths absorbed by visual pigment.

3. The system of claim 1 wherein the light source is adapted to direct light onto a foveal region of the retina.

4. The system of claim 1 wherein the sensor is adapted to be implanted within the eye, the system further comprising a lens adapted to direct light from the retina onto the sensor.

5. The system of claim 1 wherein the sensor has a substantially toroidal shape and is adapted to be implanted within the eye.

6. The system of claim 1 wherein the sensor is adapted to be implanted within the eye and to transmit data outside of the eye to the data capture and analysis system.

7. The system of claim 1 wherein the light source and the sensor are both adapted to be implanted within the eye.

8. The system of claim 1 wherein the data capture and analysis system is adapted to be disposed outside of the eye.

9. The system of claim 8 wherein the data capture and analysis system further comprises a display adapted to display glucose concentration information.

10. The system of claim 8 wherein the data capture and analysis system further comprises a receiver adapted to receive information from the sensor.

11. The system of claim 10 wherein the receiver is further adapted to receive unique identification information from the sensor.

12. The system of claim 8 wherein the data capture and analysis system further comprises a transmitter adapted to transmit power to the light source.

13. The system of claim 12 wherein the data capture and analysis system transmitter is further adapted to transmit unique identification information to the sensor.

14. The system of claim 1 wherein the support structure comprises light source support structure adapted to support the light source behind an iris of the eye and in front of a natural lens of the eye.

15. The system of claim 1 wherein the support structure comprises light source support structure adapted to support the light source behind an iris of the eye and in place of a removed natural lens of the eye.

16. The system of claim 1 wherein the light source is adapted to be disposed outside the eye and the sensor is adapted to be implanted within the eye, the support structure comprising light source support structure adapted to support the light source in front of the eye and sensor support structure adapted to support the sensor within the eye.

17. The system of claim 1 wherein the support structure comprises light source support structure, the system further comprising an implant tool adapted to insert the light source and light source support structure into the eye.

18. The system of claim 1 further comprising an insulin source adapted to provide insulin to the subject in response to blood glucose concentration calculated by the data capture and analysis system.

19. The system of claim 18 wherein the insulin source comprises a pump.

20. The system of claim 1 further comprising an alarm adapted to provide an indication of an upcoming transmission from the light source.

21. The system of claim 20 further comprising a light transmission override adapted to be operated to temporarily prevent transmission from the light source to the subject.

22. The system of claim 1 further comprising an alarm adapted to provide notice to the subject as a result of a blood glucose concentration calculated by the data capture and analysis system.

23. A method of determining blood glucose concentration of a subject comprising:

transmitting light to a retina of an eye of the subject from a light source within the eye;

receiving reflected light from the retina; and

calculating blood glucose concentration from the reflected light.

24. The method of claim 23 further comprising activating an alarm based on a result of the calculating step.

25. The method of claim 23 wherein the transmitting step comprises directing light on a foveal portion of the retina.

26. The method of claim 23 wherein the receiving step comprises receiving light reflected from the retina in a sensor disposed within the eye.

27. The method of claim 23 wherein the receiving step comprises receiving light reflected from a foveal portion of the retina in a sensor disposed within the eye.

28. The method of claim 23 wherein the receiving step comprises receiving light reflected from the retina in a sensor disposed outside the eye.

29. The method of claim 23 wherein the calculating step comprises determining a rate of change of light reflected from the retina.

30. The method of claim 23 wherein the receiving step is performed by a sensor and the calculating step is performed at least in part by a data capture and analysis system, the method further comprising transmitting information related to light reflected from the retina from the sensor to the data capture and analysis system.

31. The method of claim 30 wherein the sensor is disposed within the eye and the data capture and analysis system is disposed outside of the eye, the step of transmitting information comprising transmitting the information from within the eye to outside the eye.

32. The method of claim 31 wherein the step of transmitting information comprises transmitting unique identification information from the sensor to the data capture and analysis system.

33. The method of claim 31 further comprising transmitting unique identification information from the data capture and analysis system to the sensor.

34. The method of claim 31 wherein the step of transmitting information comprises transmitting the information from within the eye to outside the eye through a closed eye.

35. The method of claim 23 further comprising transmitting power from a source external to the eye to the light source.

36. The method of claim 23 further comprising preventing ambient light from entering the eye during the receiving step.

37. The method of claim 23 further comprising displaying blood glucose concentration.

38. The method of claim 23 further comprising automatically controlling administration of insulin from an insulin source to the subject based on blood glucose concentration.

39. The method of claim 23 further comprising, prior to the transmitting step, providing notice to the subject of an upcoming transmitting step.

40. The method of claim 39 further comprising delaying the performance of the transmitting step.

41. A method of determining blood glucose concentration of a subject comprising:

transmitting light to a retina of an eye of the subject;

receiving reflected light from the retina in a sensor disposed within the eye; and

calculating blood glucose concentration from the reflected light.

42. The method of claim 41 further comprising activating an alarm based on a result of the calculating step.

43. The method of claim 41 wherein the transmitting step comprises directing light on a foveal portion of the retina.

44. The method of claim 41 wherein the transmitting step comprises transmitting light to the retina from a light source disposed outside the eye.

45. The method of claim 41 wherein the receiving step comprises receiving light reflected from a foveal portion of the retina.

46. The method of claim 41 wherein the calculating step comprises determining a rate of change of light reflected from the retina.

47. The method of claim 41 wherein the calculating step is performed at least in part by a data capture and analysis system external to the eye, the method further comprising transmitting information related to light reflected from the retina from the sensor to the data capture and analysis system.

48. The method of claim 47 wherein the step of transmitting information comprises transmitting the information from within the eye to outside the eye through a closed eye.

49. The method of claim 47 wherein the step of transmitting information comprises transmitting unique identification information from the sensor to the data capture and analysis system.

50. The method of claim 47 further comprising displaying blood glucose concentration.

51. The method of claim 41 wherein the calculating step is performed at least in part by a data capture and analysis system external to the eye, the method further comprising transmitting unique identification information from the data capture and analysis system to the sensor.

52. The method of claim 41 further comprising automatically controlling administration of insulin from an insulin source to the subject based on blood glucose concentration.

53. The method of claim 41 further comprising, prior to the transmitting step, providing notice to the subject of an upcoming transmitting step.

54. The method of claim 53 further comprising delaying the performance of the transmitting step.

55. A method of implanting a blood glucose monitor comprising:

providing an implantable blood glucose monitor comprising a light source;

inserting the implantable blood glucose monitor through an outside surface of an eye; and

orienting the light source in a position from which the light source can illuminate at least a portion of a retina of the eye.

56. The method of claim 55 wherein the providing step comprises providing an implantable blood glucose monitor comprising a light source and a sensor adapted to receive light, the orienting step further comprising orienting the sensor to receive light from the retina.

57. The method of claim 55 wherein the inserting step comprises supporting the implantable blood glucose monitor with an insertion tool.

58. The method of claim 57 wherein the supporting step comprises supporting the implantable blood glucose monitor in an insertion state, the method further comprising moving the implantable blood glucose monitor from the insertion state to a deployed state.

59. The method of claim 55 wherein the inserting step comprises inserting the implantable blood glucose monitor into an anterior chamber of the eye.

60. The method of claim 55 wherein the inserting step comprises inserting the implantable blood glucose monitor into a posterior chamber of the eye.

61. A blood glucose monitor comprising:

a receiver adapted to be disposed outside of an eye and to receive information related to light reflected from a retina of the eye from a sensor disposed within the eye; and

a processor adapted to calculate blood glucose concentration from the information.

62. The blood glucose monitor of claim 61 wherein the receiver is further adapted to receive information related to light reflected from the sensor through a closed eye.

63. The blood glucose monitor of claim 61 further comprising a display adapted to display blood glucose concentration calculated by the processor.

64. The blood glucose monitor of claim 61 further comprising a transmitter adapted to transmit power to a light source implanted in the eye.

65. The blood glucose monitor of claim 61 further comprising a transmitter adapted to transmit a signal related to calculated blood glucose concentration to an insulin source.

66. A blood glucose monitor comprising:

a sensor adapted to be disposed outside of an eye and to receive light reflected from a retina of the eye from a light source disposed within the eye; and

a processor adapted to calculate blood glucose concentration from the information.

67. The blood glucose monitor of claim 66 further comprising a display adapted to display blood glucose concentration calculated by the processor.

68. The blood glucose monitor of claim 66 further comprising a transmitter adapted to transmit power to a light source implanted in the eye.