Sensor for detecting a target substance in a fluid

• US 20060188398A1
• Filed: 08/27/2004
• Published: 08/24/2006
• Est. Priority Date: 08/27/2003
• Status: Abandoned Application

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Okamoto, Kohei, Imamura, Takeshi, Ouchi, Toshihiko, Kuroda, Ryo, Shiotsuka, Hidenori, Yamazaki, Takeo, Yano, Koji, Sugita, Mitsuro
• Application Number:
  US10/553,977
• Publication Number:
  US 20060188398A1
• Time in Patent Office: Days
• US Class Current: 422/82.10
• CPC Class Codes: B82Y 20/00 Nanooptics, e.g. quantum optics or photonic crystals
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/39 using tunable lasers
• CPC Class Codes: G01N 21/774 the reagent being on a grating or periodic structure
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G02B 6/02347 Longitudinal structures arranged to form a regular periodic lattice, e.g. triangular, square, honeycomb unit cell repeated throughout cladding
• CPC Class Codes: G02B 6/02385 Comprising liquid, e.g. fluid filled holes
• CPC Class Codes: G02B 6/0239 Comprising means for varying the guiding properties, e.g. tuning means
• CPC Class Codes: G02B 6/1225 comprising photonic band-gap structures or photonic lattices

Abstract

A device for detecting a target substance in a fluid is provided. This device comprises a periodic structure having a vacant portion for passing the fluid containing the target substance and a solid portion arranged regularly and capable of transmitting an electromagnetic wave, an electro-magnetic wave-projecting means for projecting the electromagnetic wave to the periodic structure, and a detecting means for measuring the magnetic wave emitted from the periodic structure to detect a change in periodic distribution of a refractive index. This sensor is highly sensitive in a small size.

Claims

1. A device for detecting a target substance in a fluid, comprising

a periodic structure having a vacant portion for passing a fluid containing the target substance and a solid portion capable of transmitting an electromagnetic wave arranged regularly to form a periodic distribution of a refractive index for the electromagnetic wave,

an electromagnetic wave-projecting means for projecting the electromagnetic wave to the periodic structure, and

a detecting means for measuring the magnetic wave emitted from the periodic structure to detect a change in the periodic distribution of the refractive index.

2. The device according claim 1, wherein a trapping substance capable of bonding selectively to the target substance is disposed on the surface of the solid portion, and a change in the periodic distribution of the refractive index caused by bonding the target substance to the trapping substance is detected.

3. The device according to claim 1, wherein the periodic structure forbids transmission of the electromagnetic wave in a specific wavelength band depending on the periodic distribution of the refractive index.

4. The device according to claim 3, wherein the electromagnetic wave-projecting means for projecting the electromagnetic wave projects an electromagnetic wave with a wavelength near an edge of the wavelength band and the detecting means measures the intensity of emitted electromagnetic wave.

5. The device according to claim 3, wherein the periodic structure has a defect in the regular arrangement of the vacant portion and the solid portion to provide an electromagnetic wave-transmissive wavelength range in the wavelength band where the electromagnetic wave propagation is forbidden, the electromagnetic wave-projecting means projects the electromagnetic wave in the electromagnetic wave-transmissive wavelength range to the periodic structure, and the detecting means measures the electromagnetic wave of the electromagnetic wave-transmissive wavelength range emitted from the periodic structure.

6. The device according to claim 1, wherein the device has additionally a temperature-controlling means for controlling the temperature of the periodic structure.

7. The device according to claim 1, wherein the device has additionally a polarization-controlling means for controlling polarization of the electromagnetic wave.

8. The device according to claim 1, wherein the electromagnetic wave projected to the periodic structure has a continuous wavelength component, and the detecting means measures the spectrum of the electromagnetic wave emitted from the periodic structure.

9. The device according to claim 1, wherein the electromagnetic wave is projected through a collimating means onto the periodic structure, and the detecting means measures the direction of transmission of the electromagnetic wave.

10. The device according to claim 1, wherein the device has additionally a first aligning means for aligning the electromagnetic wave emitted from the electromagnetic wave-projecting means to enter the periodic structure at a prescribed position at a prescribed angle, and a second aligning means for aligning the electromagnetic wave to reach the detecting means.

11. The device according to claim 1, wherein the solid portions of the structure are columnar, and the vacant portion is an interstice among the structure.

12. The device according to claim 1, wherein the solid portion is a continuous body and the vacant portion is constituted of holes penetrating the continuous body.

13. A device for detecting a target substance in a fluid, comprising

a flow path for passing a fluid containing the target substance,

a periodic structure placed at least a portion of the flow path and having a vacant portion for passing the fluid containing the target substance and a solid portion capable of transmitting an electromagnetic wave arranged regularly to form a periodic distribution of a refractive index for the electromagnetic wave,

an electromagnetic wave-projecting means for projecting the electromagnetic wave to the periodic structure, and

a detecting means for measuring the magnetic wave emitted from the periodic structure to detect a change in the periodic distribution of a refractive index.

14. The device according to claim 13, wherein the periodic structure has periodic distribution of the refractive index in a direction perpendicular to the flow path, and the electromagnetic wave is projected in the direction.

15. The device according to claim 13, wherein the periodic structure has periodic distribution of the refractive index in a direction parallel to the flow path, and the electromagnetic wave is projected in the direction.

16. The device according to claim 13, wherein the periodic structure has columnar solid portions regularly placed two-dimensionally with an interspace, and the plane of the periodic structure is parallel to the flow path.

17. The device according to claim 13, wherein the periodic structure is a two-dimensional periodic structure which has a continuous solid body and holes regularly placed and penetrating the continuous body, and the holes are parallel to the flow path.

18. A device for detecting plural target substances in a fluid, comprising

a flow path for passing a fluid containing the target substances;

plural periodic structures each of which is placed at least a portion of the flow path and has a vacant portion for passing the fluid containing the target substances and a solid portion capable of transmitting an electromagnetic wave arranged regularly to form a periodic distribution of a refractive index for the electromagnetic wave,

an electromagnetic wave-projecting means for projecting the electromagnetic wave to the periodic structures, and

a detecting means for measuring the magnetic wave emitted from the periodic structures to detect a change in the periodic distribution of the refractive index.

19. The device according to claim 18, wherein the periodic structure forbids transmission of a specific wavelength band of the electromagnetic wave defined by the periodic distribution of the refractive index.

20. The device according to claim 18, wherein the periodic structures have respectively a different trapping substance distributed on the surface of the solid portion and capable of bonding to one of the target substances;

and the detecting means detects the respective changes in the periodic distribution of the refractive indexes caused by the target substance and the trapping substance.

21. The device according to claim 19, wherein the plural periodic structures are placed in series along the flow path, and plural electromagnetic wave-projecting means for projecting the electromagnetic wave in the direction perpendicular to the flow path to the respective periodic structure, and plural detecting parts for detecting the magnetic waves emitted from the periodic structures are provided.

22. The device according to claim 21, wherein the periodic structures have the same construction in the same dimension, and the electromagnetic wave-projecting means project respectively an electromagnetic wave of the wavelength near the band edge of the wavelength band while the trapping substances capable of bonding to target substances are distributed on the surface of the solid portion.

23. The device according to claim 22, wherein the periodic structures have respectively a nearly the same band edge wavelength of the wavelength band in a state that the trapping substances capable of bonding to target substances are distributed on the surface of the solid portion, and the electromagnetic wave-projecting means project respectively an electromagnetic wave of the band edge wavelength.

24. The device according to claim 18, wherein the electromagnetic waves projected to the periodic structures are generated from one and the same electromagnetic wave source, and the produced electromagnetic wave is split and projected to the periodic structures.

25. The device according to claim 19, wherein the plural periodic structures are placed in series along the flow path, and plural electromagnetic wave-projecting means for projecting the electromagnetic wave in the direction parallel to the flow path to the respective periodic structure, and plural detecting parts for detecting the magnetic waves emitted from the periodic structures are provided.

26. The device according to claim 25, wherein the periodic structures have the wavelengths not overlapping with each other, and the projected electromagnetic wave is emitted from a wavelength-variable electromagnetic wave source including the band edge wavelengths of the wavelength bands.

27. The device according to claim 19, wherein the plural periodic structures are placed in parallel in the flow path, and an electromagnetic wave-projecting means for projecting the electromagnetic wave in the parallel placement to the respective periodic structures, and a detecting unit for detecting the magnetic wave transmitted and emitted from the periodic structures are provided.

28. The device according to claim 27, wherein the periodic structures have the wavelengths not overlapping with each other, and the projected electromagnetic wave is emitted from a wavelength-variable electromagnetic wave source including the band edge wavelengths of the wavelength bands.

29. A device for detecting a target substance in a fluid, comprising

an optical fiber having plural holes for passing the fluid containing the target substance and a solid portion capable of transmitting an electromagnetic wave to form a refractive index distribution in the radius direction,

an electromagnetic wave-introducing means for introducing the electromagnetic wave to the optical fiber, and

a detecting means for measuring the magnetic wave emitted from the optical fiber in the radius direction to detect a change in a refractive index.

30. The device according to claim 29, wherein the optical fiber is a photonic crystal fiber having plural holes arranged regularly and having periodic structure of the refractive index in the fiber radius direction.

31. The device according to claim 30, wherein the trapping substance for bonding selectively to the target substance is disposed on the surface of the holes.