Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method

• US 20060188402A1
• Filed: 01/09/2006
• Published: 08/24/2006
• Est. Priority Date: 01/11/2005
• Status: Active Grant

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Xie, Tianyu, Okawa, Atsushi
• Granted Patent: US 7,966,051 B2
• Time in Patent Office: Days
• US Class Current: 422/82.80
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence

Abstract

A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.

Claims

1. A fluorescent agent concentration measuring apparatus comprising:

an excitation light source to radiate excitation light to a sample containing a body fluid taken from a living body administered with a fluorescent drug, the excitation light allowing the drug to emit fluorescence;

a fluorescence detection portion to detect the fluorescence;

a fluorescent agent concentration calculation portion to calculate the concentration of the drug in the living body, based on a detection signal from the fluorescence detection portion; and

a peak time estimation portion to estimate the peak time of the concentration of the drug in the living body tissue, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug.

2. The fluorescent agent concentration measuring apparatus according to claim 1, wherein the peak time estimation portion estimates the peak time based on a plurality of different times of day and the concentrations of the drug calculated at the plurality of times of day.

3. The fluorescent agent concentration measuring apparatus according to claim 2, comprising a curve data storage portion storing a concentration-time curve data to be compared with the concentration of the drug calculated at the plurality of times of day.

4. The fluorescent agent concentration measuring apparatus according to claim 3, comprising a communication portion to conduct transmission and reception of the data for an external server connected on the Net,

wherein at least the curve data storage portion is disposed in the external server.

5. The fluorescent agent concentration measuring apparatus according to claim 1, comprising a container loading portion to removably dispose a container including the sample solution on an optical path of the excitation light.

6. The fluorescent agent concentration measuring apparatus according to claim 5, comprising a light shield portion to shield the container loaded in the container loading portion from the external light.

7. A dose control apparatus comprising:

the fluorescent agent concentration measuring apparatus according to claim 1;

an administration start judgment portion to judge whether a predetermined time has elapsed or not and to judge the start of administration of the drug when the predetermined time has elapsed;

a dose setting portion to set at least one of the dose and the administration time of the drug, based on the predetermined dose information of the drug after the judgment of the start of administration by the administration start judgment portion;

an output apparatus to perform at least one of functions of allowing a monitor portion to display the dose and allowing an automatic administration apparatus to administer the drug, based on the dose of the drug set by the dose setting portion; and

a living body information detection portion to detect living body function information of the living body and to transmit the living body function information to the dose setting portion.

8. The dose control apparatus according to claim 7, wherein the dose information is set continuously at least one time in correspondence to the elapsed time after the judgment of the start of administration by the administration start judgment portion.

9. The dose control apparatus according to claim 7, wherein the predetermined dose information of the drug is set continuously in such a way as to decrease in correspondence to the elapsed time after the start of administration.

10. The dose control apparatus according to claim 7, wherein the predetermined dose information of the drug is set in such a way that the drug is administered at a predetermined time interval and the dose is decreased gradually after the start of administration.

11. The dose control apparatus according to claim 7, wherein the predetermined dose information of the drug is freely corrected in correspondence to previously attained metabolic information.

12. The dose control apparatus according to claim 7, wherein the automatic administration apparatus administers the drug intravenously.

13. The dose control apparatus according to claim 7, wherein the monitor portion displays the administration timing of the administration of the drug.

14. An administration system comprising:

the dose control apparatus according to claim 7;

and

an internal medical device,

wherein the internal medical device sprays the drug in a living body lumen.

15. A fluorescent agent concentration measuring method comprising:

a fluorescence detection step of detecting fluorescence from a sample containing a body fluid taken from a living body administered with a fluorescent drug;

a fluorescent agent concentration calculation step of calculating the concentration of the drug in the living body, based on a detection signal from the fluorescence detection step; and

a peak time estimation step of estimating the peak time of the concentration of the drug in the living body tissue, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug.

16. A dose control method comprising:

a fluorescence detection step of detecting fluorescence from a sample containing a body fluid taken from a living body administered with a fluorescent drug;

a fluorescent agent concentration calculation step of calculating the concentration of the drug in the living body, based on a detection signal from the fluorescence detection step;

a peak time estimation step of estimating the peak time of the concentration of the drug in the living body tissue, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug;

an administration start judgment step of judging whether a predetermined time has elapsed or not and judging the start of administration of the drug when the predetermined time has elapsed;

a dose setting step of setting at least one of the dose and the administration time of the drug, based on the predetermined dose information of the drug after the judgment of the start of administration in the administration start judgment step; and

an output step of performing at least one of functions of allowing the dose to be displayed and allowing the drug to be administered automatically, based on the dose of the drug set in the dose setting step.