Urate oxidase
First Claim
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1. A protein comprising a recombinant uricase protein of a mammalian species which has been modified to insert one or more lysine residues.
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Abstract
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
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Citations
1 Claim
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1. A protein comprising a recombinant uricase protein of a mammalian species which has been modified to insert one or more lysine residues.
Specification
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Current AssigneeDuke University
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Original AssigneeDuke University
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InventorsKelly, Susan J., Hershfield, Michael
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Application NumberUS11/357,028Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current435/191CPC Class CodesC12N 9/0046 with oxygen as acceptor (1....
