Treatment of diabetes
First Claim
Patent Images
5. A method for treating diabetes, the method comprising:
- contacting ex vivo a plurality of cells with a composition comprising at least one FACGINT and a gastrin/CCK receptor ligand, provided that the FACGINT is not an EGF receptor ligand; and
administering the cells to a mammal in need thereof, thereby treating the diabetes.
2 Assignments
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Accused Products
Abstract
Compositions and methods are provided for islet neogenesis therapy comprising a member of a group of factors that complement a gastrin/CCK receptor ligand, with formulations, devices and methods for sustained release delivery and for local delivery to target organs.
73 Citations
109 Claims
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5. A method for treating diabetes, the method comprising:
- contacting ex vivo a plurality of cells with a composition comprising at least one FACGINT and a gastrin/CCK receptor ligand, provided that the FACGINT is not an EGF receptor ligand; and
administering the cells to a mammal in need thereof, thereby treating the diabetes.
- contacting ex vivo a plurality of cells with a composition comprising at least one FACGINT and a gastrin/CCK receptor ligand, provided that the FACGINT is not an EGF receptor ligand; and
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6-8. -8. (canceled)
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11-12. -12. (canceled)
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- 16. A composition comprising a gastrin/CCK receptor ligand and a factor for complementing gastrin for islet neogenesis therapy (a FACGINT), provided that the FACGINT is not an EGF receptor ligand.
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18. (canceled)
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20. (canceled)
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22-31. -31. (canceled)
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32. A method for reducing an amount of stem cells needed for transplantation to treat human diabetes, the method comprising administering to a recipient in need thereof an effective dose of each of a gastrin/CCK receptor ligand and a FACGINT provided that the FACGINT is not an EGF receptor ligand, wherein the amount of cells needed is reduced in comparison to an amount of cells needed in the absence of administering the effective dose to an otherwise identical recipient.
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33-46. -46. (canceled)
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49-90. -90. (canceled)
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93-97. -97. (canceled)
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99-100. -100. (canceled)
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102-107. -107. (canceled)
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109-110. -110. (canceled)
Specification