Dispenser for dispensing three or more actives

• US 20060189552A1
• Filed: 01/25/2006
• Published: 08/24/2006
• Est. Priority Date: 12/12/2000
• Status: Abandoned Application

• Current Assignee: Imaginative Research Associates Incorporated
• Original Assignee: Imaginative Research Associates Incorporated
• Inventors: Vishnupad, Mohan, Vishnupad, Naomi
• Application Number:
  US11/339,650
• Publication Number:
  US 20060189552A1
• Time in Patent Office: Days
• US Class Current: 514/29
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/327 Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/02 characterised by special physical form
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/38 Percompounds, e.g. peracids
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/8147 : Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8152 : Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8158 : Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 : Polyethers
• CPC Class Codes: A61K 9/06 : Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61M 35/003 : Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003
• CPC Class Codes: A61P 17/10 : Anti-acne agents
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 : for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/04 : for chemically tanning the skin topical sun or radiation screening or tanning preparations A61Q17/04

Abstract

Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Claims

1. An apparatus comprising:

a first chamber containing a first composition, the first composition comprising a plurality of active ingredients at least one of which is effective in treating acne;

a second chamber containing a second composition comprising at least one active ingredient that is incompatible with one of the plurality of active ingredients in the first compositon;

pump means for moving the first and second compositions out of the first and second chambers, respectively; and

one or more outlets for dispensing the first and second compositions.

2. An apparatus as in claim 1 wherein the first composition comprises one or more antibiotics and one or more retinoids.

3. An apparatus as in claim 1 wherein the first composition comprises one or more antibiotics and benzoyl peroxide.

4. An apparatus as in claim 2 wherein the one or more antibiotics are selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

5. An apparatus as in claim 3 wherein the one or more antibiotic are selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

6. An apparatus as in claim 2 wherein the one or more retinoids are selected from the group consisting of retinol, retinoic acid, retinyl palmitate, retinyl propionate, retinyl acetate and synthetic retinoid mimetics.

7. An apparatus comprising:

a first chamber containing a first composition, the first composition comprising an antibiotic and a retinoid;

a second chamber containing a second composition comprising benzoyl peroxide;

pump means for moving the first and second compositions out of the first and second chambers, respectively; and

one or more outlets for dispensing the first and second compositions.

8. An apparatus as in claim 7 wherein the antibiotic is selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

9. An apparatus as in claim 7 wherein the retinoid is selected from the group consisting of retinol, retinoic acid, retinyl palmitate, retinyl propionate, retinyl acetate and synthetic retinoid mimetics.

10. An apparatus comprising:

a first chamber containing a first composition, the first composition comprising an antibiotic and benzoyl peroxide;

a second chamber containing a second composition comprising a retinoid;

pump means for moving the first and second compositions out of the first and second chambers, respectively; and

one or more outlets for dispensing the first and second compositions.

11. An apparatus as in claim 10 wherein the retinoid is selected from the group consisting of retinol, retinoic acid, retinyl palmitate, retinyl propionate, retinyl acetate and synthetic retinoid mimetics.

12. An apparatus as in claim 10 wherein the antibiotic is selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

13. A method of treating acne comprising

simultaneously pumping a first composition and a second composition from first and second chambers, respectively,

the first composition comprising an antibiotic and a retinoidt, the second composition comprising benzoyl peroxide;

and

contacting the first composition and second composition with the skin of a person afflicted with acne.

14. A method as in claim 13 wherein the antibiotic is selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

15. A method as in claim 13 wherein the retinoid is selected from the group consisting of retinol, retinoic acid, retinyl palmitate, retinyl propionate, retinyl acetate and synthetic retinoid mimetics.

16. A method of treating acne comprising

simultaneously pumping a first composition and a second composition from first and second chambers, respectively,

the first composition comprising an antibiotic and benzoyl peroxide, the second composition comprising a retinoid;

and

contacting the first composition and second composition with the skin of a person afflicted with acne.

17. A method as in claim 16 wherein the antibiotic is selected from the group consisting of erythromycin, clindamycin, tetracycline, derivatives of erythromycin, clindamycin or tetracycline and pharmaceutically acceptable salts of erythromycin, clindamycin or tetracycline.

18. A method as in claim 16 wherein benzoyl peroxide comprises from about 0.1 to about 25 weight percent of the second composition.

19. A method as in claim 16 wherein the retinoid is selected from the group consisting of retinol, retinoic acid, retinyl palmitate, retinyl propionate, retinyl acetate and synthetic retinoid mimetics.