Oxygen enhancing membrane systems for implantable devices
First Claim
1. An analyte sensing device configured for implantation into a tissue of a host, the device comprising:
- an oxygen-utilizing source;
a membrane system configured to provide at least one function selected from the group consisting of;
protection of the device from a biological environment;
diffusion resistance of an analyte;
a catalyst for enabling an enzymatic reaction; and
limitation of interfering species;
wherein the membrane system comprises a polymer material with a high oxygen solubility, wherein the membrane system is adjacent to the oxygen-utilizing source.
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Abstract
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
403 Citations
19 Claims
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1. An analyte sensing device configured for implantation into a tissue of a host, the device comprising:
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an oxygen-utilizing source;
a membrane system configured to provide at least one function selected from the group consisting of;
protection of the device from a biological environment;
diffusion resistance of an analyte;
a catalyst for enabling an enzymatic reaction; and
limitation of interfering species;
wherein the membrane system comprises a polymer material with a high oxygen solubility, wherein the membrane system is adjacent to the oxygen-utilizing source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification