Intra-aortic renal drug delivery catheter

• US 20060189960A1
• Filed: 09/07/2005
• Published: 08/24/2006
• Est. Priority Date: 01/11/1999
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: FlowMedica, Inc. (AngioDynamics, Inc.)
• Inventors: Rosenthal, Michael H., Kramer, Andrew W., Payne, Sam G., Pesotchinsky, Sophia, Kesten, Randy J.
• Granted Patent: US 7,329,236 B2
• Time in Patent Office: Days
• US Class Current: 604/509
• CPC Class Codes: A61M 2025/0034 characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores making of catheters A61M25/0009
• CPC Class Codes: A61M 2025/0035 characterized by a variable lumen cross-section by means of a resilient flexible septum or outer wall
• CPC Class Codes: A61M 2025/0036 with more than four lumina
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/0039 characterized by lumina being arranged coaxially
• CPC Class Codes: A61M 2025/004 characterized by lumina being arranged circumferentially
• CPC Class Codes: A61M 2025/1004 Balloons with folds, e.g. folded or multifolded
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1059 having different inflatable sections mainly depending on the response to the inflation pressure, e.g. due to different material properties with different compartments A61M2025/1072
• CPC Class Codes: A61M 2025/1084 having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence

Abstract

A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.

Claims

1-22. -22. (canceled)

23. A method for enhancing renal function in a patient, comprising:

diverting a portion of aortic blood flowing into a location within an abdominal aorta to flow along a diverted flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall;

injecting a volume of fluid agent into the diverted flow path within the abdominal aorta at the location;

wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the diverted flow path into their respective ostia; and

wherein the fluid agent being delivered into the plurality of renal arteries is adapted to enhance renal function.

24. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries comprises:

locally delivering a volume of vasoactive fluid agent into the plurality of renal arteries.

25. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries comprises:

locally delivering a volume of Papaverine into the plurality of renal arteries.

26. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries comprises:

locally delivering a volume of a Calcium-channel blocker into the plurality of renal arteries.

27. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries comprises:

locally delivering a volume of Nifedipine into the plurality of renal arteries.

28. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries further comprises:

locally delivering a volume of Verapamil into the plurality of renal arteries.

29. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries comprises:

locally delivering a volume of Fenoldapam into the plurality of renal arteries.

30. The method of claim 23, wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.

31. The method of claim 23, further comprising:

allowing a second portion of aortic blood to flow along a second flow path downstream across the plurality of renal artery ostia and into downstream circulation while diverting the portion of aortic blood into diverted flow path into the renal arteries and also while delivering the fluid agent into the plurality of renal arteries via the diverted flow path.

32. The method of claim 23, wherein the local delivery of fluid agent into the plurality of renal arteries further comprises:

locally delivering a volume of dopamine DA₁ agonist into the plurality of renal arteries.

33. The method of claim 23, wherein the fluid agent is delivered into the plurality of renal arteries for between about 2 and about 72 hours.

34. A system for enhancing renal function in a patient, comprising:

a delivery catheter with a proximal end portion and a distal end portion with a fluid delivery port;

a flow diverter located along the distal end portion;

a source of fluid agent;

wherein the delivery catheter is adapted to couple to the source of fluid agent;

wherein the delivery catheter is adapted to position the distal end portion at a location within an abdominal aorta associated with a plurality of renal artery ostia having unique respective positions along the abdominal aorta wall;

wherein the flow diverter at the location is adapted to divert a portion of aortic blood flow along a diverted flow path substantially only into the plurality of renal arteries via their respective ostia;

wherein the fluid delivery port is positioned relative to the flow diverter so as to inject a volume of the fluid agent from the source into the diverted flow path; and

wherein the fluid agent is adapted to enhance renal function.

35. The system of claim 34, wherein the fluid agent comprises a vasoactive agent.

36-49. -49. (canceled)