Treatment of decompression sickness with inhaled nitric oxide gas

• US 20060191535A1
• Filed: 02/25/2005
• Published: 08/31/2006
• Est. Priority Date: 02/25/2005
• Status: Abandoned Application

• Current Assignee: Nemours Foundation
• Original Assignee: Nemours Foundation
• Inventors: Tuckosh, Joseph R., Shaffer, Thomas H., Miller, Thomas L.
• Application Number:
  US11/065,748
• Publication Number:
  US 20060191535A1
• Time in Patent Office: Days
• US Class Current: 128/204.18
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/021 operated by electrical means A61M16/202 – A61M16/205 take precedence
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]

Abstract

The present invention includes a method for treating an individual suffering from decompression sickness, a gas mixture that can be used to treat the individual, and an apparatus that can be used to administer the gas mixture. The method includes administering a gas mixture of oxygen and a therapeutically effective amount of nitric oxide gas to the individual. The gas mixture can include a mixture of oxygen, helium and, nitric oxide gases. The gas mixture can be administered using an apparatus that can be worn by the individual. The apparatus includes dispensers for gases, a gas blender to mix the gases, an inspiratory passage, a face mask substantially conformable with the individual'"'"'s face, and an expiratory passage. When the individual wearing the face mask inhales, the gas mixture travels from the gas blender, through the inspiratory passage to the face mask. The gas mixture is then inhaled by the individual. When the individual exhales a breath, the breath travels from the face mask through the expiratory passage.

Claims

1. A method for treating an individual with decompression sickness, the method comprising:

administering a gas mixture to lungs of the individual, the gas mixture comprising oxygen and a therapeutically effective amount of nitric oxide gas.

2. The method of claim 1 wherein the therapeutically effective amount of nitric oxide gas is from about 1 ppm to about 100 ppm in the gas mixture.

3. The method of claim 2 wherein the therapeutically effective amount of nitric oxide gas from about 5 ppm to about 80 ppm in the gas mixture.

4. The method of claim 1 wherein the gas mixture further comprises helium.

5. The method of claim 4 wherein the helium is from about 50% to about 80% of the gas mixture based on volume of the gas mixture.

6. The method of claim 1 wherein the gas mixture is administered under positive pressure.

7. The method of claim 1 wherein the gas mixture is administered at a pressure greater than about 1 atmosphere.

8. The method of claim 7 wherein the gas mixture is administered at a pressure greater than about 2 atmospheres.

9. A method for preventing decompression sickness, the method comprising administering a gas mixture to at least one lung of a person, the gas mixture comprising oxygen and a therapeutically effective amount of nitric oxide gas.

10. The method of claim 9 wherein the therapeutically effective amount of nitric oxide gas is from about 1 ppm to about 100 ppm in the gas mixture.

11. The method of claim 10 wherein the therapeutically effective amount of nitric oxide gas is from about 5 ppm to about 80 ppm in the gas mixture.

12. A therapeutic gas mixture comprising:

oxygen, helium, and a therapeutically effective amount of gaseous nitric oxide,

wherein the nitric oxide, oxygen, and helium are mixed to create the therapeutic gas mixture.

13. The gas mixture of claim 12 wherein the therapeutically effective amount of gaseous nitric oxide is from about 1 ppm to about 100 ppm in the gas mixture.

14. The gas mixture of claim 13 wherein the therapeutically effective amount of gaseous nitric oxide is from about 5 ppm to about 100 ppm in the gas mixture.

15. The gas mixture of claim 12 wherein the helium is from about 50% to about 80% of the gas mixture based on the volume of the gas mixture.

16. The gas mixture of claim 12 wherein the gas mixture is administered under positive air pressure.

17. The gas mixture of claim 12 wherein the gas mixture is administered to a person suffering from decompression sickness.

18. The gas mixture of claim 12 wherein the gas mixture is substantially homogeneous.

19. A device for administering a gas mixture to an individual, the device comprising:

at least one dispenser of oxygen gas;

at least one dispenser of helium gas;

at least one dispenser of nitric oxide gas;

a gas blender to mix the oxygen gas, the helium gas and the nitric oxide gas into a gas mixture;

an inspiratory passage;

a face mask substantially conformable with the individual'"'"'s face; and

an expiratory passage;

wherein when the individual places the device on the individual'"'"'s face and inhales, the gas mixture travels from the gas blender, through the inspiratory passage to the face mask where the gas mixture is inhaled by the individual, and when the individual exhales a breath, the breath travels from the face mask through the expiratory passage.

20. A device of claim 19 wherein the gas mixture is a substantially homogenous blend of the oxygen gas, the helium gas, and the nitric oxide gas.

21. The device of claim 19 wherein the device further comprises a register at an end of the expiratory passage opposite the individual, the register through which the breath of the individual exits, creating a back pressure, thereby providing continuous positive airway pressure.

22. The device of claim 21 wherein the device further comprises an apparatus to measure air pressure in the device.

23. The device of claim 19 wherein the face mask is substantially conformable to the individual'"'"'s face.

24. The device of claim 23 wherein the face mask covers only a portion of the individual'"'"'s face.

25. The device is claim 19 wherein the device further comprises an apparatus to monitor the amount of the gas mixture inhaled by the individual.

26. The device of claim 19 wherein the device further comprises an apparatus to monitor the amount of gaseous nitric oxide inhaled by the individual.

27. The device of claim 19 wherein the at least one dispenser of oxygen gas, the at least one dispenser of helium gas, and the at least one dispenser of nitric oxide gas are connected to the device via tubing.