Electrochemical detection of ischemia
First Claim
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1. A device for in vitro electrochemical detection or measurement of albumin derivatives which can be diagnostic for an ischemic event, said device comprising:
- an electronics module housing comprising a display means, a data entry and control means, an aperture, internal contacts in said aperture in electrical continuity with the display means, a power source and optionally a link to a laboratory information system; and
a sample analysis strip comprising a sample well, and a plurality of electrodes, each said electrode positioned in said sample well and connected via a corresponding trace to a corresponding contact on said strip;
wherein insertion of said strip into said module housing engages each said strip contact with said corresponding contact in the module aperture, which permits electrical continuity with said display means, whereby said albumin derivatives may be detected or measured.
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Abstract
The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.
30 Citations
10 Claims
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1. A device for in vitro electrochemical detection or measurement of albumin derivatives which can be diagnostic for an ischemic event, said device comprising:
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an electronics module housing comprising a display means, a data entry and control means, an aperture, internal contacts in said aperture in electrical continuity with the display means, a power source and optionally a link to a laboratory information system; and
a sample analysis strip comprising a sample well, and a plurality of electrodes, each said electrode positioned in said sample well and connected via a corresponding trace to a corresponding contact on said strip;
wherein insertion of said strip into said module housing engages each said strip contact with said corresponding contact in the module aperture, which permits electrical continuity with said display means, whereby said albumin derivatives may be detected or measured. - View Dependent Claims (2)
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3. A device for in vitro electrochemical detection or measurement of albumin derivatives in a sample which may be diagnostic for an ischemic event, said method comprising:
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a housing having an aperture formed therein for receiving a sample analysis strip, the sample analysis strip having a sample well, a plurality of electrodes positioned in the sample well and a like plurality of first contacts interconnected to the electrodes;
control means within said housing; and
a plurality of second contacts in said aperture electrically coupled with said control means for interconnecting with the plurality of first contacts when the sample analysis strip is inserted within the aperture;
wherein, upon insertion of the sample analysis strip into said aperture, each first contact engages a corresponding second contact whereby the albumin derivatives can be detected or measured by said control means. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10)
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Specification