Method for assessing the condition of bone in-vivo

• US 20060192965A1
• Filed: 01/18/2006
• Published: 08/31/2006
• Est. Priority Date: 01/21/2005
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Shah, Natasha, Merritt, Sean, Cuccia, David, Durkin, Anthony J., Tromberg, Bruce J., Cerussi, Albert
• Application Number:
  US11/335,072
• Publication Number:
  US 20060192965A1
• Time in Patent Office: Days
• US Class Current: 356/432
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/4504 Bones A61B5/4547 takes precedence
• CPC Class Codes: A61B 5/4509 Bone density determination

Abstract

A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

Claims

1. A method for assessing bone tissue comprising:

exposing a sample to nonionizing radiation;

detecting nonionizing radiation after transit in the bone tissue;

measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and

determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

2. The method of claim 1 where measuring optical properties comprises measuring optical properties at each point in an entire fingerprint region including at least 600-1100 nm.

3. The method of claim 1 where measuring optical properties comprises measuring optical properties does not depend on arithmetic differences in tissue transit of light.

4. The method of claim 1 where measuring optical properties comprises a method for qualitative and quantitative measurements of optical properties of turbid media using frequency-domain photon migration.

5. The method of claim 1 where measuring optical properties comprises a method for performing quantitative analysis and imaging of subsurface heterogeneities of turbid media using spatially structured illumination.

6. The method of claim 1 where measuring optical properties comprises a method for combined frequency domain photon migration and broadband spectroscopy.

7. The method of claim 1 where measuring optical properties comprises a method for continuous wave broadband spectroscopy at multiple distances.

8. The method of claim 1 further comprising determining disease states based on altered bone characteristics, or determining bone disease progression based thereon.

9. The method of claim 8 where determining disease states comprises comparing bone characteristics between selected bone tissue and selected muscle tissue.

10. The method of claim 8 where determining disease states comprises determining spatial, temporal or compositional variations of bone optical properties.

11. The method of claim 8 where determining disease states comprises comparing absolute values of bone optical properties across a population.

12. The method of claim 1 further comprising correlating the optical properties of bone to provide other measures of bone including T score.

13. The method of claim 1 where measuring optical properties to characterize bone tissue comprises measuring the absorption and reduced scattering coefficients or scattering angular dependence from the bone tissue.

14. The method of claim 1 where measuring optical properties to characterize bone tissue comprises measuring the anisotropy of nonionizing optical scattering in bone.

15. The method of claim 1 where measuring optical properties to characterize bone tissue comprises using broadband DOS to measure absolute absorption spectra and characterize bound water shift in bone.

16. The method of claim 1 where measuring optical properties to characterize bone tissue comprises measuring a blue shift of a lipid absorption peak using Doppler optical spectroscopy (DOS) in bone to separate subcutaneous superficial lipids from lipids in the marrow.

17. The method of claim 1 where measuring optical properties to characterize bone tissue comprises using frequency domain photon migration (FDPM) to measure the absorption and reduced scattering properties of bone in-vivo to determine spectral changes in absorption in order to provide compositional and physiological information about the bone tissue, including a near-infrared absorption spectrum to provide concentrations of oxygenated and deoxygenated hemoglobin, lipids, and water.

18. The method of claim 1 where measuring optical properties to characterize bone tissue comprises measuring spectral changes in reduced scattering including the power and scale factor of near-infrared scattering spectral dependence of tissue as a function of the wavelength to assess bone structure and density.

19. The method of claim 1 where measuring optical properties to characterize bone tissue comprises measuring optical signals in FDPM to assess bone optical properties.

20. The method of claim 1 where determining composition, structure, or physiology of bone from the measured optical properties comprises using models of light transport, physical models, and chemometric analysis of FDPM and spectroscopic signals to determine the bone optical properties.

21. The method of claim 1 where determining composition, structure, or physiology of bone from the measured optical properties comprises using spatially structured illumination to determine the optical properties of bone to determine changes in the optical properties in bone tissue and locate inhomogeneities in bone structure or composition indicative of disease.

22. The method of claim 1 where determining composition, structure, or physiology of bone from the measured optical properties comprises analyzing tissue as a function of wavelength, illumination structure, source modulation frequency or a combination thereof to characterize bone structure and functional status.

23. The method of claim 1 further comprising performing medical diagnostics and bone density assessment based on the measurement and determination of bone tissue optical properties.

24. The method of claim 23 where performing medical diagnostics and bone density assessment comprises monitoring of therapeutic efficacy of hormone therapies and anti-osteoporosis measures.

25. The method of claim 23 where performing medical diagnostics and bone density assessment comprises monitoring changes in bone and muscle status resulting from microgravity.

26. The method of claim 23 where performing medical diagnostics and bone density assessment comprises monitoring efficacy of countermeasures for slowing or reversing the effects of microgravity.

27. The method of claim 23 where performing medical diagnostics and bone density assessment comprises monitoring recovery, healing, or treatment of bone tissue from trauma and atrophy.

28. The method of claim 23 where performing medical diagnostics and bone density assessment comprises screening osteoporosis for purpose of diagnosis or response to therapies.

29. The method of claim 23 where performing medical diagnostics and bone density assessment comprises assessing bone and muscle health in microgravity and responses to therapeutic countermeasures.

30. A apparatus for assessing bone tissue comprising:

a source of nonionizing radiation;

a detector of the nonionizing radiation after transit in the bone tissue;

means for measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and

means for determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

31. The apparatus of claim 30 where the means for measuring optical properties comprises means for measuring optical properties at each point in an entire fingerprint region including at least 600-1100 nm.

32. The apparatus of claim 30 where the means for measuring optical properties comprises means for measuring optical properties does not depend on arithmetic differences in tissue transit of light.

33. The apparatus of claim 30 where the means for measuring optical properties comprises means for qualitative and quantitative measuring optical properties of turbid media using frequency-domain photon migration.

34. The apparatus of claim 30 where the means for measuring optical properties comprises means for performing quantitative analysis and imaging of subsurface heterogeneities of turbid media using spatially structured illumination.

35. The apparatus of claim 30 where the means for measuring optical properties comprises means for combining frequency domain photon migration measurements and broadband spectroscopic measurements.

36. The apparatus of claim 30 where the means for measuring optical properties comprises means for performing continuous wave broadband spectroscopy at multiple distances.

37. The apparatus of claim 30 further comprising the means for determining disease states based on altered bone characteristics, or for determining bone disease progression based thereon.

38. The apparatus of claim 37 where the means for determining disease states comprises means for comparing bone characteristics between selected bone tissue and selected muscle tissue.

39. The apparatus of claim 37 where the means for determining disease states comprises means for determining spatial, temporal or compositional variations of bone optical properties.

40. The apparatus of claim 37 where the means for determining disease states comprises means for comparing absolute values of bone optical properties across a population.

41. The apparatus of claim 30 further means for comprising correlating the optical properties of bone to provide other measures of bone including T score.

42. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for measuring the absorption and reduced scattering coefficients or scattering angular dependence from the bone tissue.

43. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for measuring the anisotropy of nonionizing optical scattering in bone.

44. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for using broadband DOS to measure absolute absorption spectra and characterize bound water shift in bone.

45. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for measuring a blue shift of a lipid absorption peak using Doppler optical spectroscopy (DOS) in bone to separate subcutaneous superficial lipids from lipids in the marrow.

46. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for using frequency domain photon migration (FDPM) to measure the absorption and reduced scattering properties of bone in-vivo to determine spectral changes in absorption in order to provide compositional and physiological information about the bone tissue, including a near-infrared absorption spectrum to provide concentrations of oxygenated and deoxygenated hemoglobin, lipids, and water.

47. The apparatus of claim 30 where measuring optical properties to characterize bone tissue comprises measuring spectral changes in reduced scattering including the power and scale factor of near-infrared scattering spectral dependence of tissue as a function of the wavelength to assess bone structure and density.

48. The apparatus of claim 30 where the means for measuring optical properties to characterize bone tissue comprises means for measuring optical signals in FDPM to assess bone optical properties.

49. The apparatus of claim 30 where the means for determining composition, structure, or physiology of bone from the measured optical properties comprises means for using models of light transport, physical models, and chemometric analysis of FDPM and spectroscopic signals to determine the bone optical properties.

50. The apparatus of claim 30 where the means for determining composition, structure, or physiology of bone from the measured optical properties comprises means for using spatially structured illumination to determine the optical properties of bone to determine changes in the optical properties in bone tissue and locate inhomogeneities in bone structure or composition indicative of disease.

51. The apparatus of claim 30 where the means for determining composition, structure, or physiology of bone from the measured optical properties comprises means for analyzing tissue as a function of wavelength, illumination structure, source modulation frequency or a combination thereof to characterize bone structure and functional status.

52. The apparatus of claim 30 further comprising means for performing medical diagnostics and bone density assessment based on the measurement and determination of bone tissue optical properties.

53. The apparatus of claim 52 where the means for performing medical diagnostics and bone density assessment comprises means for monitoring of therapeutic efficacy of hormone therapies and anti-osteoporosis measures.

54. The apparatus of claim 52 where the means for performing medical diagnostics and bone density assessment comprises means for monitoring changes in bone and muscle status resulting from microgravity.

55. The apparatus of claim 52 where the means for performing medical diagnostics and bone density assessment comprises means for monitoring efficacy of countermeasures for slowing or reversing the effects of microgravity.

56. The apparatus of claim 52 where the means for performing medical diagnostics and bone density assessment comprises means for monitoring recovery, healing, or treatment of bone tissue from trauma and atrophy.

57. The apparatus of claim 52 where the means for performing medical diagnostics and bone density assessment comprises means for screening osteoporosis for purpose of diagnosis or response to therapies.

58. The apparatus of claim 52 where means for performing medical diagnostics and bone density assessment comprises means for assessing bone and muscle health in microgravity and responses to therapeutic countermeasures.