Film forming foamable composition
First Claim
Patent Images
1. A foamable composition, including:
- (1) about 6% to about 70% by weight of at least one organic carrier;
(2) about 0.1% to about 5% by weight of at least one surface-active agent;
(3) about 0.01% to about 5% by weight of at least one film forming agent;
(4) water; and
(5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant.
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Abstract
A foamable composition, includes (1) about 6% to about 70% by weight of at least one organic carrier; (2) about 0.1% to about 5% by weight of at least one surface-active agent; (3) about 0.01% to about 5% by weight of at least one film forming agent; (4) water; and (5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant. The composition is substantially alcohol free and is used in treating, alleviating or preventing a disorder.
331 Citations
34 Claims
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1. A foamable composition, including:
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(1) about 6% to about 70% by weight of at least one organic carrier;
(2) about 0.1% to about 5% by weight of at least one surface-active agent;
(3) about 0.01% to about 5% by weight of at least one film forming agent;
(4) water; and
(5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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2. The composition of claim 1 wherein said composition is substantially alcohol-free.
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3. The composition of claim 1, further including about 0.1% to about 5% by weight of a therapeutically active foam adjuvant is selected from the group consisting of a fatty alcohol having 15 or more carbons in their carbon chain, a fatty acid having 16 or more carbons in their carbon chain, fatty alcohols derived from beeswax and including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain, a fatty alcohol having an double bond, a fatty acid having an double bond, a branched fatty alcohol, a branched fatty acid, a fatty acid substituted with a hydroxyl group, cetyl alcohol;
- stearyl alcohol;
arachidyl alcohol, behenyl alcohol, 1-triacontanol;
hexadecanoic acid, stearic acid, arachidic acid, behenic acid, octacosanoic acid, 12-hydroxy stearic acid and mixtures thereof.
- stearyl alcohol;
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4. The composition of claim 1, further including about 0.01% to about 5% by weight of a polymeric additive selected from a gelling agent, a bioadhesive agent and a phase change agent.
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5. The composition of claim 1, wherein the film forming agent is a water-insoluble alkyl cellulose or hydroxyalkyl cellulose.
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6. The composition of claim 5, wherein the film forming agent is selected from the group consisting of alkyl cellulose, hydroxyalkyl cellulose, ethyl cellulose, propyl cellulose, butyl cellulose, cellulose acetate, hydroxypropyl cellulose, hydroxybutyl cellulose, and ethylhydroxyethyl cellulose
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7. The composition of claim 1, wherein the film forming agent is a hydrophobic, high molecular weight carboxylated acrylic copolymer.
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8. The composition of claim 7, wherein the film forming agent is selected from the group consisting of DERMACRYL-LT, DERMACRYL-79 and DERMACRYL-AQF.
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9. The composition of claim 1, wherein the film forming agent is an anionic hydrophobically modified alkali-soluble acrylic polymer emulsion.
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10. The composition of claim 9, wherein the film forming agent is selected from the group consisting of acrylates/steareth-20 methacrylate copolymer, acrylates/laureth-25 methacrylate copolymer, acrylates/beheneth-25 methacrylate copolymer, PRG-150/stearyl alcohol/SMDI and analogous acrylate copolymers.
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11. The composition of claim 1, wherein the film forming agent is selected from the group consisting of hydrophobically-modified polysaccharides, hydrophobically-modified ethoxylated urethanes, Acrylates/C10-30 Alkyl Acrylate Cross-Polymer, Acrylates/C10-30 alkyl acrylate crosspolymer, cetyl hydroxyethyl cellulose, acrylates/vinyl isodecanoate, acrylates/steareth-20 itaconate copolymer, acrylates/ceteth-20 itaconate copolymer and acrylates/aminoacrylates/C10-30 alkyl PEG 20 itaconate copolymer, polyvinylpyrrolidone/vinylacetate, polyurethane-1, polyvinylcaprolactam, polyvinylpyrrolidone/polyvinylcaprolactam, polyvinylpyrrolidone/dimethylaminopropylmethacrylamide, polyvinylpyrrolidone/polyvinylcaprolactam/dimethylaminopropylmethacrylamide, isobutylene ethylmaleimide/hydroxyethylmaleimide, polyvinyl-pyrrolidone/dimethylaminoethylmethacrylate, quaternized polyvinyl-pyrrolidone/di-methylaminoethylmethacrylate, polyvinylpyrrolidone/polyvinylcaprolactam/dimethyl-aminoethylmethacrylate, poly(vinylacetate/crotonates/vinylneodecanoate and octylacrylamide/acrylate/butylaminoethylmethacrylate.
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12. The composition of claim 1, wherein the film forming agent is chitosan.
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13. The composition of claim 1, wherein the organic carrier is selected from the group consisting of a hydrophobic organic carrier, an emollient, a polar solvent, and mixtures thereof.
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14. The composition of claim 13, wherein the organic carrier is selected from the group consisting of:
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i. Mineral oils;
ii. liquid oils originating from vegetable, marine or animal sources;
iii. liquid oils, selected from the group consisting of a saturated oil, an unsaturated oil and a polyunsaturated oil;
iv. oils selected from the group consisting of olive oil, corn oil, soybean oil, canola oil, cottonseed oil, coconut oil, sesame oil, sunflower oil, borage seed oil, syzigium aromaticum oil, hempseed oil, herring oil, cod-liver oil, salmon oil, flaxseed oil, wheat germ oil and evening primrose oil or mixtures thereof, in any proportion;
v. oils comprising at least one unsaturated fatty acid, selected from the group consisting of omega-3 fatty acids, omega-6 fatty acids, linoleic acid, linolenic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA);
vi. Unsaturated oils that possesses therapeutically-beneficial properties;
vii. essential oils;
viii. plant-derived oils;
ix. silicone oils;
x. silicone oils selected from the group consisting of polyalkyl siloxane, polyaryl siloxane, polyalkylaryl siloxane and polyether siloxane copolymer, polydimethylsiloxane(dimethicone) and poly(dimethylsiloxane)-(diphenyl-siloxane) copolymers;
xi. emollients selected from the group consisting of hexyleneglycol, propylene glycol, isostearic acid derivatives, isopropyl palmitate, isopropyl isostearate, isopropyl myristate, ethyl acetate, butyl acetate, methyl propionate, capric/caprylic triglycerides, octylmyristate, dodecyl-myristate;
diisopropyl adipate, diisopropyl dimerate, maleated soybean oil, octyl palmitate, cetyl lactate, cetyl ricinoleate, tocopheryl acetate, acetylated lanolin alcohol, cetyl acetate, phenyl trimethicone, glyceryl oleate, tocopheryl linoleate, wheat germ glycerides, arachidyl propionate, myristyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, triisocetyl citrate, octyl dodecanol, sucrose esters of fatty acids and octyl hydroxystearate;
xii. A polar solvent, selected from the group consisting of a polyol, such as glycerol (glycerin), propylene glycol, hexylene glycol, diethylene glycol, a propylene glycol n-alkanols, a terpene, a di-terpene, a tri-terpene, a terpen-ol1, limonene, menthol, dioxolane, ethylene glycol, a glycol, a sulfoxide, dimethylsulfoxide, dimethylformanide, methyl dodecyl sulfoxide, dimethylacetamide, monooleate of ethoxylated glycerides, 1-dodecylazacycloheptan-2-one and 2-(n-nonyl)-1,3-dioxolane;
xiii. Polyethylene glycol;
xiv. A Polyethylene glycol selected from the group consisting of PEG200, PEG300, PEG400, PEG600, PEG 4000, PEG 6000 and PEG 10000;
xv. A pharmaceutically or cosmetically active agent, which is semi-liquid or liquid at ambient temperature; and
xvi. A pharmaceutically or cosmetically active agent selected from the group consisting of permethrin, diethyl toluamide, dimethyl phthalate and vitamin E.
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15. The composition of claim 1, wherein the organic carrier comprises a hydrophobic carrier/emollient and a polar solvent in a ratio of between about 8:
- 1 and 1;
4.
- 1 and 1;
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16. The composition of claim 1, wherein the foamable composition is selected from the group consisting of an oil-in-water emulsion and a water-in-oil emulsion.
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17. The composition of claim 1, wherein upon release from the container, a shear-sensitive foam, having a density range selected from (1) between about 0.02 gr/mL and about 0.1 gr/mL, and (2) between about 0.02 gr/mL and about 0.1 gr/mL, is produced.
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18. The composition of claim 1, further comprising at least one active agent.
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19. The composition of claim 18, wherein the active agent is selected from the group consisting of a drug, a cosmetic active agent, an anti-infective, an antibiotic, an antibacterial agent, a disinfectant, an antifungal agent, an antiviral agent, an antiparasitic agent, an anti-inflammatory agent, an anti-allergic agent, a steroid, a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory drug, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormone, a keratolytically active agent, an alpha hydroxyl acid, a beta-hydroxy acid, vitamin A, a vitamin A derivative, a retinoid, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a burn healing agent, an anesthetic, a protein, a peptide, a neuropeptide, a allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, a sunscreen agent, an anti-wrinkle agent, a radical scavenger, a metal oxide, an anti wrinkle agent, an anti-acne agent, a skin whitening agent, a self tanning agent, an anti-cellulite agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent and mixtures thereof at any proportion;
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20. The composition of claim 18, wherein the active agent is selected from the group consisting of
i. anti-Infective agents selected from an antibiotic agent, an antibacterial agent, an anti-fungal agent, an anti-viral agent and an anti-parasite agent; -
ii. agents suitable to kill gram positive and gram-negative bacteria, protozoa, aerobic bacteria and anaerobic bacteria;
iii. antibiotic agents selected from the classes consisting of beta-lactam antibiotics, synthetic and semi-synthetic penicillins, aminoglycosides, ansa-type antibiotics, anthraquinones, antibiotic azoles, antibiotic glycopeptides, macrolides, antibiotic nucleosides, antibiotic peptides, antibiotic polyenes, antibiotic polyethers, quinolones, fluoroquinolnes, antibiotic steroids, cyclosporines, sulfonamides, tetracycline, chloramphenicol, dicarboxylic acids, salicylates, antibiotic metals, oxidizing agents, substances that release free radicals and/or active oxygen, cationic antimicrobial agents, quaternary ammonium compounds, biguanides, triguanides, bisbiguanides and analogs and polymers thereof and naturally occurring antibiotic compounds;
iv. antibiotic agents selected from the classes consisting of a strong oxidant and a free radical liberating compounds;
v. antibiotic agents selected from the group consisting of iodine, chlorohexidine and benzoyl peroxide;
vi. antifungal agents selected from the group consisting of an azole, a diazole, a triazole, miconazole, ketoconazole, clotrimazole, econazole, mebendazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, thiabendazole, tiaconazole, fluconazole, itraconazole, ravuconazole and posaconazole;
vii. antifungal agents selected from the group consisting of griseofulvin, ciclopirox, amorolfine, terbinafine, Amphotericin B, potassium iodide, flucytosine (5FC) and any combination thereof at a therapeutically effective concentration;
viii. antiviral agents selected from the group consisting of acyclovir, famciclovir, gancyclovir, valganciclovir and abacavir;
ix. corticosteroids selected from the group consisting of hydrocortisone, hydrocortisone acetate, desonide, Betamethasone, betamethasone valerate, betamethasone dipropionate, betamethasone-17-benzoate, clobetasone-17-butyrate, flucinonide, fluocinolone acetonide, alcometasone dipropionate, mometasone furoate, prednicarbate, triamcinolone acetonide, methylprednisolone aceponate, halcinonide, triamcinolone acetonide, halobetasol and clobetasol-17-propionate;
x. nonsteroidal anti-inflammatory agents selected from the group consisting of an oxicam, piroxicam, isoxicam, tenoxicam, sudoxicam, a salicylate, salicylic acid, ethyl salicylate, methyl salycilate, aspirin, disalcid, benorylate, trilisate, safapryn, solprin, diflunisal, and fendosal, an acetic acid derivative, diclofenac, fenclofenac, indomethacin, sulindac, tolmetin, isoxepac, furofenac, tiopinac, zidometacin, acematacin, fentiazac, zomepirac, clindanac, oxepinac, felbinac, ketorolac, a fenamate, mefenamic, meclofenamic, flufenamic, niflumic, tolfenamic acids;
a propionic acid derivative, ibuprofen, naproxen, benoxaprofen, flurbiprofen, ketoprofen, fenoprofen, fenbufen, indopropfen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic, a pyrazole, phenylbutazone, oxyphenbutazone, feprazone, azapropazone and trimethazone;
xi. compounds having the capacity to prevent, alleviate the symptoms of, treat or cure inflammation processes;
xii. antiallergic agents selected from the group consisting of a thylenediamine, pyrilamine, antazoline and methapyrilene, a tripelennamine phenothiazine, promethazine, methdilazine, trimeprazine, an ethanolamine, diphenhydramine, bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenylpyraline, doxylamine, phenyltoxamine, a piperazine, cyclizine, buclizine, chlorcyclizine, hydroxyzine, meclizine, thiethylperazine, an alkylamine, brompheniramine, pyrrobutamin, desbrompheniramine, tripolidine, dexchlorpherniramine, chlorpheniramine;
dimethindene, pheniramine, a piperidine, cyproheptadine and azatadine;
xiii. agents that reduce the occurrence of pro-inflammatory cytokines or inhibits the effect of pro-inflammatory cytokines;
xiv. immunoregulating agents selected from the group consisting of an immunoregulating cyclic peptide, cyclosporine, tacrolimus, tresperimus, pimecrolimus, sirolimus, verolimus, laflunimus, laquinimod and imiquimod;
xv. hormones selected from the group consisting of steroid and non-steroid hormones;
xvi. hormones selected from the group consisting of testosterone, testosterone cipionate, testosterone decanoate, testosterone enantate, testosterone isocaproate, testosterone phenylpropionate, testosterone propionate, testosterone undecylate, 5α
-dihydrotestosterone, dehydroepiandrosterone, androstenedione, androstanediol, androsterone, androstenolone, prasterone enantate, prasterone sodium sulfate, ormeloxifene, mesterolone, fluoxymesterone, methyltestosterone, gestrinone, delmadinone, delmadinone acetate, chlormadinone, chlormadinone acetate, danazol, testolactone, estradiol, estradiol benzoate, estradiol cipionate, estradiol dipropionate, estradiol enantate, estradiol hexahydrobenzoate, estradiol phenylpropionate, estradiol valerate, polyestradiol phosphate, estriol, estriol sodium succinate, estriol succinate, polyestriol phosphate, quinestradol, ethinylestradiol, estrapronicate, mestranol, estrapronicate, equilin, progesterone, norethisterone, norethisterone acetate, norethisterone enantate, medroxyprogesterone acetate, delmadinone acetate, flugestone acetate, dydrogesterone, desogestrel, norgestrel, levonorgestrel, dydrogesterone, gestodene, chlormadinone acetate, dienogest, drospirenone, lynestrenol, tybolone, cyproterone acetate, megestrol acetate and nomegestrol acetate;
xvii. keratolytically active agents selected from the group consisting of phenol, a substituted phenolic compound, dihydroxy benzene, resorcinol, hydroquinone, lactic acid, glycolic acid, citric acid, malic acid, a beta-hydroxy acid, salicylic acid and urea;
xviii. retinoids selected from the group consisting of retinol, retinal, all trans retinoic acid, retinyl acetate, retinyl palmitate, retinyl ascorbate, etretinate, actiretin, isotretinoin, adapalene and tazarotene;
xix. dicarboxylic acids selected from the group consisting of azelaic acid, sebacic acid, adipic acid, fumaric acid;
xx. topical anesthetic agents selected from the group consisting of benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, cocaine, ketamine, pramoxine, benzyl alcohol and phenol;
xxi. insecticides or an insect repellent agents selected from the group consisting of permethrin, hexachlorobenzene, carbamate, a naturally occurring pyrethroid, permethrin, allethrin, malathion, piperonyl butoxide, diethyl-m-toluamide), dimethyl phthalate;
xxii. sunscreen agents selected from the group consisting of p-aminobenzoic acid, p-dimethylaminobenzoic acid, an anthranilate, an o-amino-benzoate ester a salicylate esters, a cinnamic acid derivative, a-phenyl cinnamonitrile, butyl cinnamoyl pyruvate, a dihydroxycinnamic acid derivative, umbelliferone, methylumbelliferone, methylaceto-umbelliferone, a trihydroxy-cinnamic acid derivative, esculetin, methylesculetin, daphnetin, esculin, daphnin, diphenylbutadiene, stilbene, dibenzalacetone, benzalacetophenone, a naphtholsulfonate, 2-naphthol-3,6-disulfonic, 2-naphthol-6,8-disulfonic acids, dihydroxynaphthoic acid, an o-hydroxybiphenyldisulfonate, a p-hydroxybiphenyldisulfonate, a coumarin derivative, a diazole, 2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthoxazole, an aryl benzothiazoles, a quinine salt, a quinoline derivative, 8-hydroxyquinoline, 2-phenylquinoline, a;
hydroxy- or methoxy-substituted benzophenone, uric acid, violuric acids, tannic acid, hexaethylether, hydroquinone;
a benzophenones, oxybenzene, sulisobenzone, dioxybenzone, benzoresorcinol, 2,2′
,4,4′
-tetrahydroxybenzophenone, 2,2′
-dihydroxy-4,4′
-dimethoxybenzophenone, octabenzone;
4-isopropyldibenzoylmethane;
butylmethoxydibenzoylmethane;
etocrylene;
octocrylene;
[3-(4′
-methylbenzylidene bornan-2-one), terephthalylidene dicamphor sulfonic acid and 4-isopropyl-di-benzoylmethane, a metallic oxide, titanium dioxide, zinc oxide, zirconium oxide and iron oxide;
xxiii. photodynamic therapy agents selected from the group consisting of modified porphyrins, chlorins, bacteriochlorins, phthalocyanines, naphthalocyanines, pheophorbides, purpurins, m-THPC, mono-L-aspartyl chlorine, bacteriochlorins, phthalocyanines, benzoporphyrin derivatives and aminolevulinic acid;
xxiv. agents capable of treating a disorder selected from acne, wrinkles and scars. xxv. active agents selected from the group consisting of a phenol, resorcinol, sulfur, salicylic acid, a sulfur-containing amino acid, N-acetyl derivatives, a thiol, hyaluronic acid, phytic acid, lipoic acid, lysophosphatidic acid, vitamin B, niacinamide, nicotinic acid, tocopheryl nicotinate, a nicotinyl amino acid, a nicotinyl alcohol ester of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide;
xxvi. anti-oxidant or a radical scavengers selected from the group consisting of ascorbic acid, an ascorbyl ester of fatty acids, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate, tocopherol, tocopherol sorbate, tocopherol acetate, butylated hydroxy benzoic acid, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, gallic acid, sorbic acid, lipoic acid, N,N-diethylhydroxylamine, amino-guanidine, a sulfhydryl compoun, glutathione), dihydroxy fumaric acid, lycine pidolate, arginine pilolate, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, methionine, proline, superoxide dismutase, silymarin, tea extract, grape skin extract, grape seed extract, melanin and rosemary extract;
xxvii. Dihydroxyacetone;
xxviii. insoluble inorganic compounds selected from the group consisting of titanium dioxide, zinc oxide, zirconium oxide, iron oxide, silicone oxide, talc, carbon, calcium, magnesium hypochlorite and metallic Silver;
xxix. plant seed meal selected from the group consisting of strawberry seeds, raspberry seeds, apricot seeds, sweet almond seeds and cranberry seeds; and
xxx. oil comprising fatty acids selected from the group consisting of an unsaturated polyunsaturated fatty acid, a polyunsaturated fatty acid, an omega-3 fatty acid, an omega-6 fatty acid, linoleic and linolenic acid, gamma-linoleic acid and eicosapentaenoic acid and derivatives, isomers and analogs thereof.
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21. The composition of claim 19, wherein the composition comprises at least two active agents.
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22. The composition of claim 21, wherein each of the at least two active agents exerts its therapeutic effect through at different mode of action.
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23. The composition of claim 1, wherein the film forming agent is selected from the group consisting of (1) hydrophobic, high-molecular-weight, carboxylated acrylic copolymers;
- (2) anionic hydrophobically modified alkali-soluble acrylic polymers; and
(3) acrylates/alkyl acrylate crosspolymers;
and wherein the active agent is semi-liquid or liquid at ambient temperature.
- (2) anionic hydrophobically modified alkali-soluble acrylic polymers; and
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24. The composition of claim 23, wherein the active agent is selected from the group consisting of diethyltoluamide, diethyl phthalate, a sunscreen agent and permethrin.
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25. The composition of claim 1, wherein the concentration of film forming agent is sufficient to elevate skin hydration, in use, in a human subject for at least 1 hour.
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26. The composition of claim 1, wherein the concentration of film forming agent is sufficient to elevate skin availability of an active agent, in use.
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27. The composition of claim 1, wherein the propellant contains at least one compressed gas selected form the group of (1) volatile hydrocarbons;
- and (2) fluorocarbon gases.
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28. The composition of claim 1, wherein the propellant contains at least one compressed gas selected form the group of:
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i. hydrocarbons selected from the group consisting of butane, propane and isobutene;
ii. fluorocarbon gases selected from the group consisting of 1,1,difluoro ethane, 1,1,1,2 tetrafluorethane, 1,1,1,3,3,3 hexafluoropropane and 1,1,1,2,3,3,3 heptafluoropropane.
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2. The composition of claim 1 wherein said composition is substantially alcohol-free.
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29. A method of treating, alleviating or preventing a disorder, including:
administering topically to a surface having the disorder, a foamed composition including;
(1) about 6% to about 70% by weight of an organic carrier;
(2) about 0.1% to about 5% by weight of a surface-active agent;
(3) about 0.01% to about 5% by weight of a film forming agent;
(4) water;
(5) about 3% to about 25% by weight of the total composition of a liquefied or compressed gas propellant; and
(6) an active agent. - View Dependent Claims (30, 31, 32, 33, 34)
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30. The method of claim 29, wherein the composition further includes about 0.1% to about 5% by weight of a foam adjuvant selected from the group consisting of a fatty alcohol having 15 or more carbons in their carbon chain;
- a fatty acid having 16 or more carbons in their carbon chain;
fatty alcohols derived from beeswax and including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain;
a fatty alcohol having an double bond;
a fatty acid having an double bond;
a branched fatty alcohol;
a branched fatty acid;
a fatty acid substituted with a hydroxyl group;
cetyl alcohol;
stearyl alcohol;
arachidyl alcohol;
behenyl alcohol;
1-triacontanol;
hexadecanoic acid;
stearic acid;
arachidic acid;
behenic acid;
octacosanoic acid;
12-hydroxy stearic acid and mixtures thereof.
- a fatty acid having 16 or more carbons in their carbon chain;
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31. The method of claim 29, wherein the active agent is selected from the group consisting of a drug, a cosmetic active agent, an anti-infective, an antibiotic, an antibacterial agent, a disinfectant, an antifungal agent, an antiviral agent, an antiparasitic agent, an anti-inflammatory agent, an anti-allergic agent, a steroid, a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory drug, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormone, a keratolytically active agent, an alpha hydroxyl acid, a beta-hydroxy acid, vitamin A, a vitamin A derivative, a retinoid, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a burn healing agent, an anesthetic, a protein, a peptide, a neuropeptide, a allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, a sunscreen agent, an anti-wrinkle agent, a radical scavenger, a metal oxide, an anti wrinkle agent, an anti-acne agent, a skin whitening agent, a self tanning agent, an anti-cellulite agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent and mixtures thereof at any proportion.
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32. The method of claim 29, wherein the disorder is selected from the group of insect infestation and insect bite;
- and wherein active agent is selected from the group consisting of permethrin, pyrethrum extract, piperonyl butoxide, diethyl toluamide and dimethyl phthalate
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33. The method of claim 29, wherein the disorder is selected from the sunburn and a skin disiease, which results from UV light radiation;
- and wherein active agent is a sunscreen agent
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34. The method of claim 29, wherein the disorder is a skin disordser which involves skin dryness as a primary etiological factor;
- and wherein active agent comprises at least two agents, selected from the group consisting of avocado oil, a silicone oil, cyclomethicone, dimethicone, aloe vera extract, sodium hyaluronate, licorice extract, alpha bisabolol, tocopheryl acetate and allantoin.
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30. The method of claim 29, wherein the composition further includes about 0.1% to about 5% by weight of a foam adjuvant selected from the group consisting of a fatty alcohol having 15 or more carbons in their carbon chain;
Specification
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Current AssigneeFoamix Pharmaceuticals, Ltd. (VYNE Therapeutics, Inc.)
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Original AssigneeFoamix Ltd. (VYNE Therapeutics, Inc.)
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InventorsFriedman, Doron, Tamarkin, Dov, Eini, Meir
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Application NumberUS11/337,747Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current424/47CPC Class CodesA01N 25/16 FoamsA61K 2800/75 Anti-irritantA61K 8/046 Aerosols; FoamsA61K 8/06 EmulsionsA61K 8/062 Oil-in-water emulsionsA61K 8/31 HydrocarbonsA61K 9/0014 Skin, i.e. galenical aspect...A61K 9/107 Emulsions ; Emulsion precon...A61K 9/122 Foams; Dry foams edible foa...A61Q 17/02 containing insect repellantsA61Q 19/00 Preparations for care of th...A61Q 19/10 Washing or bathing preparat...