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Polypeptide variants with altered effector function

  • US 20060194290A1
  • Filed: 05/08/2006
  • Published: 08/31/2006
  • Est. Priority Date: 01/15/1999
  • Status: Abandoned Application
First Claim
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1. A polypeptide comprising a variant Fc region which displays reduced binding to an Fcγ

  • R and comprises an amino acid substitution at any one or more of amino acid positions 238, 239, 248, 249, 252, 254, 265, 268, 269, 270, 272, 278, 289, 292, 293, 294, 295, 296, 298, 301, 303, 322, 324, 327, 329, 333, 335, 338, 340, 373, 376, 382, 388, 389, 414, 416, 419, 434, 435, 437, 438 or 439 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat.

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