Fluid handling cassette with a fluid control interface

• US 20060194325A1
• Filed: 12/21/2005
• Published: 08/31/2006
• Est. Priority Date: 02/14/2005
• Status: Abandoned Application

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Gable, Jennifer H., Braig, James R., Zheng, Peng, Li, Kenneth I., Wechsler, Mark, Keenan, Richard
• Application Number:
  US11/316,701
• Publication Number:
  US 20060194325A1
• Time in Patent Office: Days
• US Class Current: 436/45
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/1427 Multiple blood sampling, e.g. at periodic or pre-established intervals
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150267 Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150755 : Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150862 : intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/150992 : Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 : Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 : Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 : Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4839 : combined with drug delivery
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3306 : Optical measuring means
• CPC Class Codes: A61M 2230/20 : Blood composition characteristics
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 5/14212 : Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/14232 : Roller pumps
• CPC Class Codes: A61M 5/16854 : by monitoring line pressure
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/365 : Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: A61M 5/38 : using hydrophilic or hydrophobic filters
• CPC Class Codes: G01N 2021/3595 : using FTIR
• CPC Class Codes: G01N 21/03 : Cuvette constructions
• CPC Class Codes: G01N 21/3577 : for analysing liquids, e.g. polluted water
• CPC Class Codes: G01N 2201/02 : Mechanical
• CPC Class Codes: G01N 2201/061 : Sources
• CPC Class Codes: Y10T 137/4478 : Line condition change responsive
• CPC Class Codes: Y10T 137/7722 : Line condition change responsive valves
• CPC Class Codes: Y10T 137/86485 : Line condition change responsive release of valve
• CPC Class Codes: Y10T 436/111666 : Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

A fluid handling and analysis system is provided. The system includes a main analysis and control instrument and a fluid handling module that are removably engageable with the main instrument. The main instrument comprises a spectroscopic bodily fluid analyzer and at least one control element. The fluid handling module includes a spectroscopic sample cell and at least one fluid handling element, and the sample cell is accessible via the fluid handling element. The fluid handling element has a control interface configured to engage the control element when the main instrument and the fluid handling module are engaged.

Claims

1. A fluid handling and analysis system comprising:

a main analysis and control instrument; and

a fluid handling module removably engageable with said main instrument;

said main instrument comprising a spectroscopic bodily fluid analyzer and at least one control element;

said fluid handling module comprising a spectroscopic sample cell and at least one fluid handling element wherein said sample cell is accessible via said fluid handling element;

said at least one fluid handling element having a control interface configured to engage said at least one control element when said main instrument and said fluid handling module are engaged.

2. The system of claim 1, wherein said at least one fluid handling element is selected from the group consisting of a fluid passageway, a syringe, and a centrifuge rotor.

3. The system of claim 1, wherein said at least one control element is selected from the group consisting of a valve actuator, a pump actuator, a syringe drive and a centrifuge drive.

4. The system of claim 1, wherein said at least one control element is operatively configured to control fluid flow through said at least one fluid handling element.

5. The system of claim 1, wherein said at least one control element is operatively configured to control fluid communication between said spectroscopic sample cell and said fluid handling element.

6. The system of claim 1, wherein said fluid handling module further comprises a module body wherein said at least one control element interface is accessible to a control element of said main instrument through said module body.

7. The system of claim 6, wherein said module body encloses said at least one fluid handling element, said module body further comprising at least one opening operably positioned to provide access to said at least one control element interface.

8. The system of claim 7, wherein said at least one control element interface comprises a passageway portion extending across said at least one opening in said module body.

9. The system of claim 7, wherein said module body further encloses said sample cell, said module body comprising an opening operably positioned to allow access to said sample cell.

10. The system of claim 1, wherein said sample cell comprises at least one window.

11. The system of claim 10, wherein said window is constructed of a material through which infrared radiation can pass into said sample cell.

12. The system of claim 10, wherein said sample cell comprises at least two windows.

13. The system of claim 12, wherein said windows are constructed of a material through which infrared radiation can pass into said sample cell.

14. The system of claim 1, wherein said sample cell is reagentless.

15. A fluid handling module removably engageable with a bodily fluid analyzer, said module comprising:

a fluid handling network;

a spectroscopic analysis cell accessible via said fluid handling network;

said fluid handling network comprising at least one fluid handling element;

said at least one fluid handling element comprising at least one control element interface.

16. The module of claim 15, wherein said at least one fluid handling element is selected from the group consisting of a fluid passageway, a syringe, and a centrifuge rotor.

17. The module of claim 15, wherein said at least one control element interface is configured to engage a control element of said bodily fluid analyzer.

18. The module of claim 17, wherein said at least one control element is selected from the group consisting of a valve actuator, a pump actuator, a syringe drive and a centrifuge drive.

19. The module of claim 15, further comprising a module body wherein said at least one control element interface is accessible to a control element of said bodily fluid analyzer through said module body.

20. The module of claim 19, wherein said module body encloses said at least one fluid handling element, said module body further comprising at least one opening operably positioned to facilitate access to said at least one control element interface.

21. The module of claim 20, wherein said at least one control element interface comprises a passageway portion extending across said at least one opening in said module body.

22. The module of claim 15, wherein said sample cell comprises at least one window.

23. The module of claim 22, wherein said window is constructed of a material which allows infrared radiation to pass into said sample cell.

24. The module of claim 15, wherein said sample cell comprises at least two windows.

25. The module of claim 24, wherein said windows are constructed of a material which allow infrared radiation to pass through said sample cell.

26. The module of claim 15, wherein said sample cell is reagentless.

27. A method for extracting and analyzing a bodily fluid of a patient, said method comprising:

attaching a fluid handling module to a main analysis and control instrument, wherein;

said fluid handling module comprises at least one fluid handling element having a control element interface, and a spectroscopic sample cell accessible via said fluid handling element; and

said main instrument comprises a bodily fluid analyzer and at least one control element;

engaging said control element interface of at least one fluid handling element with said at least one control element of said main instrument; and

controlling fluid flow between said at least one fluid handling element and said spectroscopic sample cell with said control element.

28. The method of claim 27, comprising connecting said fluid handling module to said bodily fluid in said patient, wherein said controlling comprises drawing a sample of said bodily fluid from said patient into said spectroscopic sample cell.

29. The method of claim 28, further comprising the steps of:

interfacing said spectroscopic sample cell with said bodily fluid analyzer; and

analyzing said sample of said bodily fluid with said bodily fluid analyzer to measure the concentration of an analyte.

30. The method of claim 29, wherein said spectroscopic sample cell comp/rises at least one window and said interfacing comprises aligning said at least one window with said bodily fluid analyzer.

31. The method of claim 28, wherein:

said at least one fluid handling element comprises a centrifuge rotor;

said at least one control element comprises a centrifuge drive motor; and

said engaging comprises interfacing said centrifuge rotor with said drive motor.

32. The method of claim 31, wherein said controlling fluid flow comprises separating a first component from said bodily fluid in said fluid handling element and transporting said first component towards said spectroscopic sample cell.

33. The method of claim 28, wherein:

said at least one fluid handling element comprises a fluid passageway;

said at least one control element comprises a valve actuator; and

said controlling comprises selectively controlling fluid communication along said fluid passageway.

34. The method of claim 33, wherein said controlling comprises controlling fluid communication between said spectroscopic sample cell and said fluid handling element.

35. The method of claim 27, wherein:

said at least one fluid handling element comprises a syringe;

said at least one control element comprises a syringe drive; and

said engaging comprises interfacing said syringe with said drive motor.