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Sensor chips

  • US 20060194343A1
  • Filed: 01/06/2006
  • Published: 08/31/2006
  • Est. Priority Date: 07/08/2003
  • Status: Active Grant
First Claim
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1. A method for selectively orienting and immobilizing molecules on a surface of a solid support, the method comprising:

  • attaching a linker molecule to the surface of the solid support, the linker molecule including a head group that is capable of binding to the solid support, and a tail group that is capable of chelating to a metal ion;

    treating the solid support with a solution containing the metal ion so that the metal ion is chelated to the tail group;

    attaching a metal ion chelating tag to the molecules to form tagged molecules; and

    capturing the tagged molecules on the solid support by contacting it with the tagged molecules to form a monolayer of molecules on the surface of the solid support in which a majority of the molecules are held in the same orientation with respect to the surface.

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