Compositions and methods for treating tissue ischemia
First Claim
1. A method of treating tissue ischemia comprising administering to a subject a therapeutically effective amount of a CXCR4 antagonist, wherein the CXCR antagonist elevates the peripheral blood endothelial progenitor cell (EPC) count of the subject, thereby treating the tissue ischemia in the subject.
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Abstract
The present invention generally provides methods for preventing or treating tissue ischemia using CXCR4 antagonists. In one embodiment, the methods include administering to a mammal a therapeutically effective amount of a particular bicylic polyamine to elevate peripheral blood EPCs. The invention has a wide spectrum of applications including reducing or eliminating tissue ishemica associated with a myocardial infarct (heart attack).
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Citations
25 Claims
- 1. A method of treating tissue ischemia comprising administering to a subject a therapeutically effective amount of a CXCR4 antagonist, wherein the CXCR antagonist elevates the peripheral blood endothelial progenitor cell (EPC) count of the subject, thereby treating the tissue ischemia in the subject.
Specification