Fluid handling cassette having a fluid transport network

• US 20060195045A1
• Filed: 12/21/2005
• Published: 08/31/2006
• Est. Priority Date: 02/14/2005
• Status: Abandoned Application

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Gable, Jennifer H., Braig, James R., Zheng, Peng, Li, Kenneth I., Wechsler, Mark, Keenan, Richard, Witte, Kenneth G.
• Application Number:
  US11/314,963
• Publication Number:
  US 20060195045A1
• Time in Patent Office: Days
• US Class Current: 600/583
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/1427 Multiple blood sampling, e.g. at periodic or pre-established intervals
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150267 Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150755 : Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150862 : intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/150992 : Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 : Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 : Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 : Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4839 : combined with drug delivery
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3306 : Optical measuring means
• CPC Class Codes: A61M 2230/20 : Blood composition characteristics
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 5/14212 : Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/14232 : Roller pumps
• CPC Class Codes: A61M 5/16854 : by monitoring line pressure
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/365 : Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: A61M 5/38 : using hydrophilic or hydrophobic filters
• CPC Class Codes: G01N 2021/3595 : using FTIR
• CPC Class Codes: G01N 21/03 : Cuvette constructions
• CPC Class Codes: G01N 21/3577 : for analysing liquids, e.g. polluted water
• CPC Class Codes: G01N 2201/02 : Mechanical
• CPC Class Codes: G01N 2201/061 : Sources
• CPC Class Codes: Y10T 137/4478 : Line condition change responsive
• CPC Class Codes: Y10T 137/7722 : Line condition change responsive valves
• CPC Class Codes: Y10T 137/86485 : Line condition change responsive release of valve
• CPC Class Codes: Y10T 436/111666 : Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module comprises a housing, an infusion fluid passageway, a sample fluid passageway, and a fluid component separator. The infusion fluid passageway has a first port and a second port spaced from the first port, and a lumen extending from the first port to the second port. The sample fluid passageway is connected to the infusion fluid passageway. The fluid component separator is connected to the sample fluid passageway.

Claims

1. A fluid handling module configured for removable engagement with a reusable main fluid handling instrument, said module comprising:

a housing;

an infusion fluid passageway having a first port and a second port spaced from said first port, and a lumen extending from said first port to said second port;

a sample fluid passageway connected to said infusion fluid passageway; and

a fluid component separator connected to said sample fluid passageway.

2. The fluid handling module of claim 1, wherein at least a portion of said infusion fluid passageway is enclosed by said housing.

3. The fluid handling module of claim 1, wherein at least a portion of said infusion fluid passageway extends from said housing.

4. The fluid handling module of claim 1, wherein the sample fluid passageway is in fluid communication with the infusion fluid passageway.

5. The fluid handling module of claim 1, wherein said fluid component separator is configured to remove at least a first component from a sample of bodily fluid drawn into said module.

6. The fluid handling module of claim 5, wherein the fluid component separator comprises a filter.

7. The fluid handling module of claim 6, wherein the filter is located in said sample fluid passageway.

8. The fluid handling module of claim 5, wherein the fluid component separator comprises a centrifuge.

9. The fluid handling module of claim 5, wherein the fluid component separator comprises a centrifuge rotor.

10. The fluid handling module of claim 9, wherein said centrifuge rotor is configured to interface with a centrifuge drive located on said main fluid handling instrument.

11. The fluid handling module of claim 5, further comprising a sample analysis cell in fluid communication with said fluid component separator.

12. The fluid handling module of claim 11 wherein said sample analysis cell is configured to hold at least a portion of said first component.

13. The fluid handling module of claim 5, wherein fluid component separator further comprises a sample analysis cell.

14. The fluid handling module of claim 5, further comprising a waste receptacle accessible via said sample fluid passageway.

15. The fluid handling module of claim 1, wherein the fluid component separator is located within said housing.

16. The fluid handling module of claim 1, wherein the fluid component separator is located on said housing.

17. A fluid handling module configured for removable engagement with a reusable main fluid handling instrument, said module comprising:

a module housing;

a first fluid passageway extending from said module housing, said first fluid passageway having a patient end remote from said housing, said first fluid passageway configured to provide fluid communication with a bodily fluid in a patient; and

a fluid component separator in fluid communication with said first fluid passageway, said fluid component separator configured to separate at least one component from a portion of said bodily fluid drawn from said patient.

18. The fluid handling module of claim 17, wherein the first fluid passage way further comprises an infusion end extending from the module housing and configured to be connected to an infusion source.

19. The fluid handling module of claim 17, wherein the patient end of the first fluid passageway further comprises a connector configured to provide fluid communication with a bodily fluid in a patient.

20. The fluid handling module of claim 17, further comprising a draw passageway, said draw passageway providing fluid communication between said fluid component separator and said first fluid passageway.

21. The fluid handling module of claim 20, wherein said fluid component separator is configured to remove at least a first component from a sample of bodily fluid.

22. The fluid handling module of claim 21, wherein the fluid component separator comprises a filter.

23. The fluid handling module of claim 22, wherein the filter is located in said draw passageway.

24. The fluid handling module of claim 21, wherein the fluid component separator comprises a centrifuge.

25. The fluid handling module of claim 21, wherein the fluid component separator comprises a centrifuge rotor.

26. The fluid handling module of claim 25, wherein said centrifuge rotor is configured to interface with a centrifuge drive located on said main fluid handling instrument.

27. The fluid handling module of claim 21, further comprising a sample analysis cell in fluid communication with said fluid component separator.

28. The fluid handling module of claim 27, wherein said sample analysis cell is configured to hold a portion of said first component.

29. The fluid handling module of claim 17, wherein said fluid component separator further comprises a sample analysis cell.

30. The fluid handling module of claim 17, further comprising a waste receptacle accessible via said first fluid passageway.

31. A method for extracting and preparing for analysis a bodily fluid of a patient, said method comprising:

attaching a removeable fluid handling module to a main fluid handling instrument, wherein;

said fluid handling module comprises a module body, a fluid component separator connected to said module body, and a fluid passageway extending from said module body; and

said main fluid handling instrument comprises an analyte detection system;

drawing a volume of a bodily fluid from said patient into said fluid passageway;

transferring at least a portion of said drawn volume of bodily fluid to said fluid component separator;

with said fluid component separator, separating a first component from said bodily fluid;

with said analyte detection system, analyzing at least a portion of said separated first component to determine a concentration of an analyte.

32. The method of claim 31, further comprising maintaining fluid communication between said fluid handling module and said patient'"'"'s vasculature while performing said analyzing.

33. The method of claim 32, wherein said fluid passageway further comprises an infusion end spaced from said module, said method further comprising:

connecting said fluid passageway with an infusion source; and

periodically infusing a liquid from said infusing source into said patient'"'"'s vasculature.

34. The method of claim 31, wherein said fluid component separator comprises a filter and said separating comprises flowing said bodily fluid through said filter.

35. The method of claim 31, wherein said fluid component separator comprises a centrifuge and said separating comprises using centrifugal force to separate said first component from said bodily fluid.

36. The method of claim 31, wherein said fluid component separator comprises a centrifuge rotor, and wherein said main instrument further comprises a centrifuge drive, and wherein said attaching comprises interfacing said centrifuge rotor with said centrifuge drive.

37. The method of claim 36, wherein said separating comprises using centrifugal force to separate said first component from said bodily fluid.

38. The method of claim 31, further comprising transporting said first component to a sample analysis chamber.

39. The method of claim 38, wherein said sample analysis chamber is operatively configured to interface with said analyte detection system