Engineering vascularized muscle tissue
First Claim
Patent Images
1. A tissue engineered construct, comprising:
- endothelial cells;
muscle cells; and
a three-dimensional support matrix on which the endothelial cells and the muscle are seeded.
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Abstract
A tissue engineered construct. The construct includes endothelial cells, muscle cells, and a three-dimensional support matrix on which the endothelial cells and the myoblasts are seeded.
30 Citations
63 Claims
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1. A tissue engineered construct, comprising:
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endothelial cells;
muscle cells; and
a three-dimensional support matrix on which the endothelial cells and the muscle are seeded. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A tissue-engineered muscle construct, comprising:
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a three-dimensional support matrix;
a plurality of myotubes disposed within the support matrix; and
at least one endothelial vessel structure disposed within the support matrix. - View Dependent Claims (30)
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31. A tissue-engineered muscle construct, comprising:
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a three-dimensional support matrix;
a plurality of cardiac muscle cells disposed within the support matrix; and
at least one endothelial vessel structure disposed within the support matrix. - View Dependent Claims (32)
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33. A method of producing a tissue engineered construct, comprising:
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providing a population of endothelial cells;
providing a population of muscle cells;
seeding the endothelial cells and the muscle cells on a three-dimensional support matrix; and
culturing the seeded cell support matrix in a predetermined medium for a predetermined period of time. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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Specification