Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
First Claim
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1. A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell;
- and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject.
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Abstract
A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
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Citations
37 Claims
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1. A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell;
- and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject.
- View Dependent Claims (2, 3, 5, 6, 7, 9, 10, 17)
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4. (canceled)
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8. (canceled)
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11-16. -16. (canceled)
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18. A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) inducing differentiation of a progenitor cell, in vitro, to a cell that is destined to be cardiogenic;
- and (ii) administering a therapeutically effective amount of the cell of step (i) to the subject, thereby treating the cardiac disorder in the subject.
- View Dependent Claims (19, 20, 22, 23, 24, 26, 27, 34)
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21. (canceled)
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25. (canceled)
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28-33. -33. (canceled)
- 35. A method for inducing differentiation of a progenitor cell to a cardiogenic cell, in vitro, comprising forming an embryoid body cell aggregate of progenitor cells.
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37-54. -54. (canceled)
Specification