Patch material for ionic medicine administration

• US 20060198879A1
• Filed: 03/09/2004
• Published: 09/07/2006
• Est. Priority Date: 03/10/2003
• Status: Active Grant

• Current Assignee: Tokuyama Corporation
• Original Assignee: Tokuyama Corporation
• Inventors: Fukuta, Kenji, Sakata, Kanji
• Granted Patent: US 7,479,132 B2
• Time in Patent Office: Days
• US Class Current: 424/448
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

The present invention discloses a patch for use in administration of an ionic medicine into a living body by infiltration of the ionic medicine into the living body through the living body surface without voltage application, characterized in that the patch comprises an ion-exchange membrane having a surface roughness (Rz) of 7 μm or less at its part to be brought into contact with the living body surface and an ionic medicine impregnated into the ion-exchange membrane.

Claims

1. A patch for use in administration of an ionic medicine into a living body by infiltration of the ionic medicine into the living body through the living body surface without voltage application, characterized in that the patch comprises an ion-exchange membrane having a surface roughness (Rz) of 7 μ

m or less at its part to be brought into contact with the living body surface and an ionic medicine impregnated into the ion-exchange membrane.

2. The patch according to claim 1, wherein the ion-exchange membrane comprises a porous membrane made of a thermoplastic resin as the base material and an ion-exchange resin contained in voids of the base material.

3. The patch according to claim 2, wherein the ion-exchange resin is a crosslinked ion-exchange resin.

4. The patch according to claim 1, wherein an adhesive layer has been formed along the periphery of the part of the ion-exchange membrane to be brought into contact with the living body surface.

5. A patch for use in administration of an ionic medicine into a living body by infiltration of the ionic medicine into the living body through the living body surface without voltage application, characterized in that the patch comprises an ion-exchange membrane having a surface roughness (Rz) of 7 μ

m or less at its part to be brought into contact with the living body surface, an ionic medicine impregnated into the ion-exchange membrane, and an ionic medicine-containing layer formed on the side of the ion-exchange membrane opposite to its side having the part to be brought into contact with the living body surface.

6. The patch according to claim 5, wherein the ion-exchange membrane comprises a porous membrane made of a thermoplastic resin as the base material and an ion-exchange resin contained in voids of the base material.

7. The patch according to claim 6, wherein the ion-exchange resin is a crosslinked ion-exchange resin.

8. The patch according to claim 5, wherein an adhesive layer has been formed along the periphery of the part of the ion-exchange membrane to be brought into contact with the living body surface.