Porous ceramic composite bone grafts
First Claim
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1. A porous ceramic composite implant, said implant comprising;
- a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of said ceramic matrix, wherein said biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout said porous ceramic matrix and improves mechanical properties of said implant.
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Abstract
The invention relates to porous ceramic composites incorporating biodegradable polymers for use as a bone substitute in the fields of orthopaedics and dentistry or as a scaffold for tissue engineering applications. The porous ceramic composite implant for connective tissue replacement comprises a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of the ceramic matrix. The biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout the porous ceramic matrix and improves mechanical properties of the implant in vivo.
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Citations
46 Claims
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1. A porous ceramic composite implant, said implant comprising;
a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of said ceramic matrix, wherein said biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout said porous ceramic matrix and improves mechanical properties of said implant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of making a porous ceramic implant for connective tissue replacement, said method comprising;
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(i) impregnating an organic reticulated foam structure with a slurry of calcium-phosphate compound;
(ii) drying the impregnated foam structure to form a slurry coated foam structure; and
(iii) pyrolyzing the slurry coated foam structure formed in (ii) and sintering to provide a fused ceramic porous implant having a plurality of interconnected voids. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification