Optimized sensor geometry for an implantable glucose sensor
First Claim
1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
- a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the body is substantially cylindrical defined by a curved lateral surface and two ends, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body.
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Accused Products
Abstract
An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.
321 Citations
29 Claims
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1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the body is substantially cylindrical defined by a curved lateral surface and two ends, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body comprising a sensing region on a first surface of said body, wherein said first surface comprises a continuous curvature substantially across the entire surface such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the body comprises substantially cylindrical configuration defined by a curved lateral surface and two ends, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body. - View Dependent Claims (21, 22, 23, 24)
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25. A wholly implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:
a wholly implantable body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of a first surface of said body and wherein said first surface comprises a porous material thereon, wherein the body is substantially cylindrical defined by a curved lateral surface and two ends, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body. - View Dependent Claims (26, 27, 28, 29)
Specification