Noninvasive nonlinear systems and methods for predicting seizure
First Claim
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1. A system for predicting ictal onset in a subject comprising:
- a. a first data sensor positioned on the scalp of a subject near the focal point of ictal onset;
b. a second data sensor positioned on the scalp of said subject, wherein said second data sensor is remote from said first data sensor; and
c. a processor configured to analyze data collected from said first and said second data sensors to provide a nonlinear mathematical manipulation of said data collected from said first and from said second data sensors, wherein said nonlinear mathematical manipulation produces a first marginal predictability value, and a second marginal predictability value.
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Abstract
The present invention relates to methods and devices for noninvasive nonlinear prediction of ictal onset in patients afflicted by neurological disease. In particular, the present invention provides methods and devices for noninvasive nonlinear prediction of seizures in patients afflicted with epilepsy. The devices and methods preferably being based on analysis of two or more electroencephalogram (EEG) recordings, one set of recordings taken from an electrode close to the region of ictal onset, and a second or more set of recordings (e.g., concurrent readings) taken from a region remote from the region of ictal onset.
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21 Claims
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1. A system for predicting ictal onset in a subject comprising:
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a. a first data sensor positioned on the scalp of a subject near the focal point of ictal onset;
b. a second data sensor positioned on the scalp of said subject, wherein said second data sensor is remote from said first data sensor; and
c. a processor configured to analyze data collected from said first and said second data sensors to provide a nonlinear mathematical manipulation of said data collected from said first and from said second data sensors, wherein said nonlinear mathematical manipulation produces a first marginal predictability value, and a second marginal predictability value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for predicting ictal onset in a subject comprising:
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a. providing;
i. a subject;
ii. a system configured to detect ictal onset, wherein said system comprises;
a first data sensor positioned on the scalp of said subject near the focal point of ictal onset;
a second data sensor positioned on the scalp of said subject, wherein said second data sensor is remote from said first data sensor;
iii. a processor configured to analyze data collected from said first and said second data sensors to provide a nonlinear mathematical manipulation of said data collected from said first and from said second data sensors, wherein said nonlinear mathematical manipulation produces a first marginal predictability value, and a second marginal predictability value; and
iv. a subject warning device in communication with said processor; and
b. contacting said subject with said system;
c. determining said first marginal predictability value and a second marginal predictability value;
d. predicting ictal onset in said patient by difference in said first marginal predictability value and a second marginal predictability value. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification