Transcutaneous analyte sensor

• US 20060200970A1
• Filed: 05/02/2006
• Published: 09/14/2006
• Est. Priority Date: 07/13/2004
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brister, Mark, Masterson, Steve, Thrower, James Patrick, Saint, Sean, Neale, Paul V., Kline, Daniel S., Codd, Daniel Shawn
• Application Number:
  US11/415,999
• Publication Number:
  US 20060200970A1
• Time in Patent Office: Days
• US Class Current: 29/593
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0276 Determining malfunction
• CPC Class Codes: A61B 2560/028 Arrangements to prevent overuse, e.g. by counting the number of uses
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6832 using adhesives A61B5/259 takes precedence
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61L 2/12 Microwaves
• CPC Class Codes: A61L 2/206 : Ethylene oxide
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 29/49004 : including measuring or testing of device or component part

Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Claims

1. A method for manufacturing a transcutaneous analyte sensor, the method comprising the steps of:

coating a first wire with a substantially non-conductive material;

twisting the first wire and a second wire into a helical configuration; and

depositing a membrane system onto the twisted first wire and second wire.

2. The method of claim 1, wherein the step of twisting comprises twisting the first wire and second wire onto a coil.

3. The method of claim 1, wherein the step of twisting the first wire and second wire further comprises forming a plurality of distinct helical portions.

4. The method of claim 3, wherein the step forming a plurality of distinct helical portions further comprises forming indexing therebetween.

5. The method of claim 4, wherein the indexing has a substantially non-twisted configuration.

6. The method of claim 1, wherein the step of depositing comprises serially depositing a plurality of membrane layers.

7. The method of claim 6, wherein the plurality of membrane layers are deposited on a continuous coil of the twisted first wire and second wire.

8. The method of claim 7, further comprising cutting a plurality of sensors from the continuous coil.

9. The method of claim 1, further comprising drying the membrane system.

10. The method of claim 1, wherein the sensor is at least partially manufactured using a continuous reel-to-reel process.

11. The method of claim 1, wherein the sensor is wholly manufactured using a continuous reel-to-reel process.

12. The method of claim 1, wherein at least one step is automated.

13. The method of claim 1, wherein the steps are conducted substantially without manual mounting and fixturing steps.

14. The method of claim 1, wherein the steps are conducted substantially without human interaction.

15. The method of claim 1, wherein the step of depositing a membrane system comprises depositing an electrode domain configured to provide hydrophilicity at at least one exposed electrochemically reactive surface.

16. The method of claim 1, wherein the step of depositing a membrane system comprises depositing an interference domain configured to restrict flow of at least one interferant therethrough.

17. The method of claim 1, wherein the step of depositing a membrane system comprises depositing an enzyme domain comprising an enzyme and configured to catalyze a reaction of the analyte and a co-reactant.

18. The method of claim 1, wherein the step of depositing a membrane system comprises depositing a resistance domain configured to control flux of the analyte therethrough.

19. The method of claim 1, further comprising the step of exposing an electroactive portion of the first electrode.

20. The method of claim 1, further comprising the step of coating the twisted first wire and second wire with a non-conductive material.