High-flow oxygen delivery system and methods of use thereof

• US 20060201504A1
• Filed: 03/08/2005
• Published: 09/14/2006
• Est. Priority Date: 03/08/2005
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Sorensen, A. Gregory, Hess, Dean, Koroshetz, Walter J., Lo, Eng H., Singhal, Aneesh B.
• Application Number:
  US11/075,990
• Publication Number:
  US 20060201504A1
• Time in Patent Office: Days
• US Class Current: 128/204.180
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/101 using an oxygen concentrator
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/03 Gases in liquid phase, e.g. cryogenic liquids
• CPC Class Codes: A62B 9/003 Means for influencing the temperature or humidity of the breathing gas

Abstract

A device and method of its use for the treatment or prevention of an acute ischemic condition by administering high concentrations of oxygen or an oxygen- containing gas at normobaric pressure and a flow rate of 10 L/min or greater.

Claims

1. An oxygen delivery apparatus comprising:

a) a source of oxygen; and

b) means for delivering, to the respiratory system of a human patient, oxygen from said source of oxygen at a flow rate of 10 L/min or greater at normal or near-normal atmospheric pressure, wherein said apparatus is adapted such that the apparatus is;

i) portable, and

ii) MRI-compatible.

2. The apparatus of claim 1, wherein said source of oxygen comprises 90% to 100% oxygen.

3. The apparatus of claim 2, wherein said source of oxygen comprises 100% oxygen.

4. The apparatus of claim 1, wherein said flow rate is between 25 L/min and 60 L/min.

5. The apparatus of claim 4, wherein said flow rate is 40 L/min.

6. The apparatus of claim 1, wherein said apparatus is manufactured using non-metallic, non-ferromagnetic, or non-paramagnetic material.

7. The apparatus of claim 6, wherein said material is plastic or silicon.

8. The apparatus of claim 1, wherein said means for delivering oxygen to said patient comprises a facemask coupled to said source of oxygen.

9. The apparatus of claim 1, further comprising humidifying means for humidifying the oxygen from said source.

10. The apparatus of claim 1, further comprising end-tidal capnometer and capnometer sensor means.

11. The apparatus of claim 10, wherein said end-tidal capnometer further comprises an alarm and automatic shutoff that prevents the flow of oxygen to said patient, both of which activate when said capnometer sensor means detects expiratory partial pressure of arterial carbon dioxide (paCO₂) levels of greater than 40 mm Hg or greater than 10% or more of baseline values.

12. The apparatus of claim 1, further comprising gas demand valve means that allows the flow of oxygen during inspiration of the patient.

13. A method of reducing acute ischemic damage in a human patient comprising delivering oxygen to the respiratory system of said patient at a flow rate of 25 L/min or greater at normal or near-normal atmospheric pressure.

14. The method of claim 13, wherein said acute tissue damage is caused by subarachnoid hemorrhage, brain hemorrhage, brain trauma, head injury, a seizure, a headache disorder, cardiovascular disease, tissue organ engraftment rejection, sequelae of ischemic reperfusion injury, retinal ischemia, gastrointestinal ischemia, or peripheral ischemia.

15. The method of claim 14, wherein said cardiovascular disease is myocardial infarction, heart disease, coronary artery disease, congestive heart failure, cardiac valvular disease, cardiac arrhythmia, or cardiac arrest.

16. The method of claim 14, wherein said retinal ischemia is caused by diabetic retinopathy, central retinal artery or vein occlusion, stenosis of the carotid artery, retinal detachment, retinal tearing, or sickle cell retinopathy.

17. The method of claim 14, wherein said gastrointestinal ischemia is ischemic bowel, ischemic colitis, or mesenteric ischemia.

18. The method of claim 14, wherein said headache disorder is migraine or cluster headache.

19. The method of claim 14, wherein said peripheral ischemia is acute peripheral vascular ischemia, atherosclerosis, peripheral arterial occlusive disease, thromboembolic disease, or thromboangiitis obliterans (Buerger'"'"'s disease).

20. The method of claim 13, wherein said acute ischemic damage occurs in the brain, heart, peripheral nervous system, bowels, kidney, or retina.

21. The method of claim 13, wherein said method delivers 95% oxygen to the respiratory system.

22. The method of claim 21, wherein said method delivers 100% oxygen to the respiratory

23. The method of claim 13, wherein said oxygen is delivered to said patient using delivery means.

24. The method of claim 23, wherein said delivery means comprises a facemask coupled to a source of oxygen.

25. The method of claim 13, wherein said flow rate is between 25 L/min and 60 L/min.

26. The method of claim 24, wherein said flow rate is 40 L/min.