Hydroalcoholic antimicrobial composition with skin health benefits

• US 20060204466A1
• Filed: 03/08/2005
• Published: 09/14/2006
• Est. Priority Date: 03/08/2005
• Status: Abandoned Application

• Current Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Original Assignee: Ecolab, Inc.
• Inventors: Littau, Cheryl A., Le, Mai T.
• Application Number:
  US11/075,287
• Publication Number:
  US 20060204466A1
• Time in Patent Office: Days
• US Class Current: 424/70.130
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 49/00 Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group , wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group , wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof containing hydrocarbons A01N27/00
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

The invention pertains to an alcohol based antimicrobial skincare composition. The invention also pertains to an alcohol based antimicrobial skincare composition with skin health benefits including moisturization and skin barrier maintenance effects. The invention further pertains to an alcohol based antimicrobial skincare composition that is a stable emulsion that has a certain viscosity to it that provides containment, for example on a user'"'"'s hands. Finally, the invention pertains to an alcohol based antimicrobial skincare composition that may be used in the healthcare industry, for example as a surgical scrub, healthcare personnel handwash, or patient pre-operative site preparation.

Claims

1. An antimicrobial composition comprising:

a) a lower chain alcohol;

b) a preservative;

c) a terpenoid;

d) a skin conditioner;

e) a thickener; and

f) an emulsifier.

2. The composition of claim 1, wherein the lower chain alcohol is a C₂-C₄ alcohol.

3. The composition of claim 1, wherein the alcohol is ethanol.

4. The composition of claim 1, wherein the preservative is selected from the group consisting of phenolics, halogens, quaternary ammonium compounds, metal derivatives, amines, alkanolamines, nitro derivatives, biguanides, analides, organosulfur compounds, sulfur-nitrogen compounds, and mixtures thereof.

5. The composition of claim 1, wherein the terpenoid is selected from the group consisting of famesol, nerolidol, bisabolol, apritone, and mixtures thereof.

6. The composition of claim 1, wherein the skin conditioner is selected from the group consisting of emollients, humectants, occlusive agents, and mixtures thereof.

7. The composition of claim 1, wherein the thickener is a cellulosic thickener.

8. The composition of claim 1, wherein the emulsifier is an alkylene oxide ether of a fatty alcohol.

9. The composition of claim 1, wherein

a) the alcohol is present from about 50 to about 95 wt. %;

b) the preservative is present from about 0.5 to about 3 wt. %;

c) the terpenoid is present from about 0.005 to about 5 wt. %;

d) the skin conditioner is present from about 0.01 to about 15 wt. %;

e) the thickener is present from about 0.01 to about 5 wt. %; and

f) the emulsifier is present from about 0.1 to about 8 wt. %.

10. The composition of claim 1, further comprising additional functional ingredients.

11. The composition of claim 10, wherein the additional functional ingredients are selected from the group consisting of skin feel improvers, antioxidants, fragrances, dyes, and mixtures thereof.

12. The composition of claim 1, wherein the composition has a viscosity from about 1,800 to about 15,000 centipoise.

13. The composition of claim 1, wherein the composition has a viscosity from about 2,000 to about 10,000 centipoise.

14. The composition of claim 1, wherein at least one ingredient performs a dual function.

15. The composition of claim 1, wherein the preservative is selected from the group consisting of polyaminopropylbiguanide, benzethonium chloride, benzalkonium chloride, and mixtures thereof.

16. The composition of claim 1, wherein the composition produces at least a 2.5 log reduction of Serratia marcescens within 5 minutes of contact.

17. The composition of claim 1, wherein the composition produces at least a 3 log reduction of Serratia marcescens within 5 minutes of contact.

18. The composition of claim 1, wherein the composition produces at least a 3 log reduction of at least a 5 log baseline population of resident flora within 1 minute of contact after 5 days of use.

19. The composition of claim 1, wherein the composition produces at least a 3.5 log reduction of at least a 5 log baseline population of resident flora within 1 minute of contact after five days of use.

20. The composition of claim 1, wherein the composition produces at least a 4.0 log reduction of at least a 5 log baseline population of resident flora within 1 minute of contact after five days of use.

21. The composition of claim 1, wherein the composition produces a Δ

conductivity measurement of at least 18 as measured using a Skicon-200 with a MT8C probe.

22. The composition of claim 1, wherein the composition produces a Δ

conductivity measurement of at least 24 as measured using a Skicon-200 with a MT8C probe.

23. The composition of claim 1, wherein the composition produces a Δ

conductivity measurement of at least 28 as measured using a Skicon-200 with a MT8C probe.

24. The composition of claim 1, wherein the composition is substantially free of anionic ingredients.

25. A method of disinfecting a substrate comprising the step of applying to the substrate an effective amount of the composition of claim 1.

26. The method of claim 25, wherein the substrate is human skin.

27. The method of claim 25, wherein the substrate is a hand.

28. The method of claim 25, wherein the substrate is an injection site.

29. The method of claim 25, wherein the substrate is a surgical site.

30. An alcohol based antimicrobial emulsion comprising:

a) a C₂-C₄ alcohol;

b) a preservative selected from the group consisting of halogens, quaternary ammonium compounds, biguanides, and mixtures thereof;

c) a terpenoid selected from the group consisting of famesol, nerolidol, bisabolol, apritone, and mixtures thereof;

d) a skin conditioner selected from the group consisting of emollients, humectants, occlusive agents, and mixtures thereof;

e) a thickener in an amount sufficient to provide the composition with a viscosity from about 800 to about 20,000 centipoise; and

f) an emulsifier.

31. An antimicrobial foam composition comprising:

a) a lower chain alcohol;

b) a preservative;

c) a terpenoid; and

d) a skin conditioner.

32. The composition of claim 31, wherein the composition is dispensed as a mousse.

33. The composition of claim 31, wherein the composition is dispensed as an aerosol.