Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems
First Claim
1. A dendrimeric polymer with symmetric chemical structure or non-symmetric hyperbranched polymer, characterized in that the polymer is modified so as to comprise:
- at least one atom of a chemical element able to form three or more chemical bonds various different terminal functional groups bonded to said at least one atom, which terminal functional groups, together;
a) have low toxicity or no toxicity at all, b) render the molecules of the above polymers recognizable from the complementary receptors of the cells, c) render the polymers stable in a biological environment and d) facilitate the transport of the said polymers through cell membranes.
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Abstract
The present invention deals with the synthesis of multifunctional dendrimeric and hyperbranched polymers for application as drug delivery systems of bioactive pharmaceutical compounds and as gene delivery systems (carriers of genetic material), the latter through condensation with genetic material. Specifically, the present invention deals with the synthesis of multifunctional compounds based on appropriate dendrimeric or hyperbranched polymers at the terminal surface of which have been introduced functional groups X, Y, Z. In addition, for gene delivery to cells these multifunctional systems will become cationic for the formation of complexes with negatively charged genetic material. The functional groups render the delivery systems recognizable by complementary cell receptors. Furthermore they render the systems stable in the biological milieu and facilitate their transport through cell membranes.
14 Citations
27 Claims
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1. A dendrimeric polymer with symmetric chemical structure or non-symmetric hyperbranched polymer, characterized in that the polymer is modified so as to comprise:
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at least one atom of a chemical element able to form three or more chemical bonds various different terminal functional groups bonded to said at least one atom, which terminal functional groups, together;
a) have low toxicity or no toxicity at all, b) render the molecules of the above polymers recognizable from the complementary receptors of the cells, c) render the polymers stable in a biological environment and d) facilitate the transport of the said polymers through cell membranes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification