Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
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Abstract
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other'"'"'s rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.
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Citations
29 Claims
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1-9. -9. (canceled)
- 10. A biodegradable ocular implant comprising an active agent and a biodegradable polymer, wherein the active agent is a cyclosporine, the biodegradable polymer is a polylactic acid, polyglycolic acid co-polymer, and the implant being formed for subconjunctival insertion.
- 20. A biodegradable ocular implant comprising an active cyclosporine and a biodegradable polylactic acid, polyglycolic acid copolymer, the implant being sized and shaped for subconjunctival insertion.
Specification