Multiple phase cross-linked compositions and uses thereof
First Claim
1. A pharmaceutical composition comprising a matrix capable of delivering at least one therapeutic agent to a bodily compartment under controlled release conditions, said matrix comprising a homogenous mixture of an aqueous phase and at least one other phase, at least one therapeutic agent present in at least one of said phases, and at least one cross-linked polymer physically entrapping said at least one therapeutic agent.
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Accused Products
Abstract
The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.
26 Citations
21 Claims
- 1. A pharmaceutical composition comprising a matrix capable of delivering at least one therapeutic agent to a bodily compartment under controlled release conditions, said matrix comprising a homogenous mixture of an aqueous phase and at least one other phase, at least one therapeutic agent present in at least one of said phases, and at least one cross-linked polymer physically entrapping said at least one therapeutic agent.
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21-37. -37. (canceled)
Specification