Medical device applications of nanostructured surfaces
First Claim
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1. A composition for coating a medical device, comprising:
- a plurality of nanostructures, and a matrix material, wherein the plurality of nanostructures are dispersed in the matrix material.
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Abstract
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
527 Citations
118 Claims
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1. A composition for coating a medical device, comprising:
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a plurality of nanostructures, and a matrix material, wherein the plurality of nanostructures are dispersed in the matrix material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46)
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17. The composition of 16, wherein:
the van der Waals forces comprise from about 2.0 N/cm2 to about 10 N/cm2.
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40. The composition of 39, wherein:
the van der Waals forces comprise from about 2.0 N/cm2 to about 10 N/cm2.
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47. A method of administering a composition to a patient, comprising:
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providing a composition-eluting device, said composition-eluting device comprising a plurality of nanostructures, and introducing the composition-eluting device into the body of the patient. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 71, 72)
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70. The method of 69, wherein:
the van der Waals forces comprise from about 2.0 N/cm2 to about 10 N/cm2.
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73. A composition, comprising:
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a plurality of nanostructures, and a matrix material, wherein the plurality of nanostructures are dispersed in the matrix material, and wherein the composition is flowable. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80)
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81. A medical device having antibacterial properties, comprising:
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a plurality of nanostructures, and a plurality of nanoparticles associated with the plurality of nanostructures, wherein the nanoparticles comprise a material selected from the group consisting of Ag and/or Zn. - View Dependent Claims (82, 83, 84, 85, 86)
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87. A method for controlling differentiation of stem cells, comprising:
providing a substrate for growing cells, said substrate comprising a plurality of nanostructures, a population of stem cells, and at least one growth factor compound capable of promoting cell reproduction. - View Dependent Claims (88, 89, 90, 91)
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92. The method of controlling differentiation of stem cells of claim wherein:
the plurality of nanostructures comprise a material independently selected from the group consisting of silicon, glass, quartz, metals and metal alloys, inorganic polymers and copolymers, thermoset plastics, organic polymers including proteins, TiO, ZnO, ZnS, ZnSe, ZnTe, CdS, CdSe, CdTe, HgS, HgSe, HgTe, MgS, MgSe, MgTe, CaS, CaSe, CaTe, SrS, SrSe, SrTe, BaS, BaSe, BaTe, GaN, GaP, GaAs, GaSb, InN, InP, InAs, InSb, PbS, PbSe, PbTe, AlS, AlP, AlSb, Ge, SiGe, SiO, SiO2, silicon carbide and silicon nitride. - View Dependent Claims (93, 94, 95)
- 96. An aneurysm coil having a plurality of nanostructures associated therewith.
- 101. A medical device substrate comprising at least a first surface comprising a thin layer of silicon deposited on the surface, and a plurality of silicon or silicon oxide nanofibers grown on the silicon layer.
- 111. A method of growing silicon nanowires on a surface of a medical device comprising depositing a thin layer of silicon on the surface, and depositing silicon nanowires on the thin layer of silicon.
Specification