Dual path immunoassay device
First Claim
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1. A test device for determining the presence of a ligand in a liquid sample, comprising:
- a) a first sorbent strip having a first location for receiving a solution and defining a first migration path;
b) a second sorbent strip distinct from said first sorbent strip having a second location for receiving the liquid sample and defining a second migration path distinct from said first migration path; and
c) a test site located on or in at least one of said first sorbent strip or said second sorbent strip, said test site having an immobilized ligand-binding mechanism, and said first and second sorbent strips touching each other at the test site.
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Abstract
The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules such as aptamers, nucleic acids, etc. located at the junction of the first and second sorbent materials. The first and second sorbent strips touch each other at the test site location.
114 Citations
35 Claims
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1. A test device for determining the presence of a ligand in a liquid sample, comprising:
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a) a first sorbent strip having a first location for receiving a solution and defining a first migration path;
b) a second sorbent strip distinct from said first sorbent strip having a second location for receiving the liquid sample and defining a second migration path distinct from said first migration path; and
c) a test site located on or in at least one of said first sorbent strip or said second sorbent strip, said test site having an immobilized ligand-binding mechanism, and said first and second sorbent strips touching each other at the test site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25-32. -32. (canceled)
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33. A test device for determining the presence of a ligand in a liquid sample, comprising:
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a) a first sorbent strip having a first location for receiving a solution and defining a first migration path;
b) a second sorbent strip distinct from said first sorbent strip having a second location for receiving the liquid sample and defining a second migration path distinct from said first migration path; and
c) a test site located on or in at least one of said first or second sorbent strips, said test site having an immobilized ligand-binding mechanism deposited on or in the at least one of said first or second sorbent strips, said first and second sorbent strips in direct contact with each other at the test site.
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34. (canceled)
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35. (canceled)
Specification