×

Spiroazacyclic compounds as monoamine receptor modulators

  • US 20060205710A1
  • Filed: 05/03/2006
  • Published: 09/14/2006
  • Est. Priority Date: 12/28/2001
  • Status: Active Grant
First Claim
Patent Images

1. A compound of formula I, salts and stereoisomers thereof embedded imagewherein X is selected from the group consisting of CH2, CH2CH2, CH2O, OCH2, O, CH2S, SCH2, S, CH2N(RN), N(Rk)CH2 and N(RN);

  • wherein RN is selected from hydrogen and C1-6 alkyl;

    Y is selected from the group consisting of O and S;

    Z is absent or selected from the group consisting of CH and N;

    R1 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, optionally substituted C3-6 cycloalkyl, aryl, and heteroaryl;

    m is selected from the group consisting of 0 and 1, wherein if m is 1 and X is CH2 or N(RN), then Z is absent, and if m is 1 and X is O, then Z is CH or N, and if m is 0 and X is 0, then Z is N or absent;

    R4, R5, and R6 are independently selected from the group consisting of hydrogen, C1-6 alkyl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), heterocyclyl(C1-6 alkyl), hydroxy(C1-6 alkyl), amino(C1-6 alkyl), halo(C1-6 alkyl), optionally substituted C3-6 cylcoalkyl, aryl, and heteroaryl, wherein at least two of R4, R5, and R6 are independently selected from the group consisting of aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), and heterocyclyl(C1-6 alkyl);

    R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C1-6 alkyl or selected such that R2 and R3 together form a ring system such that embedded imageis selected from the group consisting of embedded imagewherein R7 and R8 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and C1-6 alkyl.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×