Medicinal arylethanolamine compounds
First Claim
Patent Images
1. A compound of formula (I):
- or a salt, solvate, or physiologically functional derivative thereof, wherein;
Ar1 is a group selected from wherein R4 represents hydrogen, halogen, —
(CH2)qOR7, —
NR7C(O)R8, —
NR7SO2R8, —
SO2NR7R8, —
NR7R8, —
OC(O)R9 or OC(O)NR7R8, and R3 represents hydrogen, halogen or C1-4 alkyl;
or R4 represents —
NHR10 and R3 and —
NHR10 together form a 5- or 6-membered heterocyclic ring;
R5 represents hydrogen, halogen, —
OR7 or —
NR7R8;
R6 represents hydrogen, halogen, haloC1-4alkyl, —
OR7, —
NR7R8, —
OC(O)R9 or OC(O)NR7R8;
R7 and R8 each independently represents hydrogen or C1-4 alkyl, or in the groups —
NR7R8, —
SO2NR7R8 and —
OC(O)NR7R8, R7 and R8 independently represent hydrogen or C1-4 alkyl or together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered nitrogen-containing ring, R9 represents an aryl group which may be unsubstituted or substituted by one or more substituents selected from halogen, C1-4 alkyl, hydroxyl, C1-4 alkoxy or halo C1-4 alkyl; and
q is zero or an integer from 1 to 4;
Ar2 is a group;
wherein R11 is selected from hydrogen, C1-6alkyl, hydroxy, C1-6alkoxy, cyano, nitro, halo, C1-6haloalkyl, XCO2R16, —
XC(O)NR15R16, —
XNR14C(O)R15, —
XNR14C(O)NR15R16, —
XNR14C(O)NC(O)NR15R16, —
XNR14SO2R15, —
XSO2NR17R18, XSR14, XSOR14, XSO2R14, —
XNR15R16, —
XNR14C(O)OR15, or XNR14SO2NR15R16, or R11 is selected from —
X-aryl, —
X-hetaryl, or —
X-(aryloxy), each optionally substituted by 1 or 2 groups independently selected from hydroxy, C1-6alkoxy, halo, C1-6alkyl, C1-6haloalkyl, cyano, nitro, CONR15R16, —
NR14C(O)R15, SR14, SOR14, —
SO2R14, —
SO2NR17R18, —
CO2R16, —
NR15R16, or hetaryl optionally substituted by 1 or 2 groups independently selected from hydroxy, C1-6alkoxy, halo, C1-6alkyl, or C1-6haloalkyl;
X is —
(CH2)r—
or C2-6 alkenylene;
r is an integer from 0 to 6;
R14 and R15 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, hetaryl, hetaryl(C1-6alkyl)- and aryl(C1-6alkyl)- and R14 and R15 are each independently optionally substituted by 1 or 2 groups independently selected from halo, C1-6alkyl, C3-7 cycloalkyl, C1-6 alkoxy, C1-6haloalkyl, —
NHC(O)(C1-6alkyl), —
SO2(C1-6alkyl), —
SO2(aryl), —
CO2H, and —
CO2(C1-4alkyl), —
NH2, —
NH(C1-6alkyl), aryl(C1-6alkyl)-, aryl(C2-6alkenyl)-, aryl(C2-6alkynyl)-, hetaryl(C1-6alkyl)-, —
NHSO2aryl, —
NH(hetarylC1-6alkyl), —
NHSO2hetaryl, —
NHSO2(C1-6alkyl), —
NHC(O)aryl, or —
NHC(O)hetaryl;
or R14 and R15, together with the nitrogen atom to which they are bonded, form a 5-, 6- or 7-membered nitrogen—
containing ring;
or where R11 is —
XNR14C(O)NR15R16, R14 and R15 may, together with the —
NC(O)N—
portion of the group R1 to which they are bonded, form a saturated or unsaturated ring or where R11 is —
XNR14C(O)OR15, R14 and R15 may, together with the —
NC(O)O—
portion of the group R11 to which they are bonded, form a saturated or unsaturated ring;
R16 is selected from hydrogen, C1-6alkyl and C3-7 cycloalkyl;
or where R11 is —
XC(O)NR15R16 or —
XNR14C(O)NR15R16, R15 and R16 may, together with the nitrogen to which they are bonded, form a 5-, 6-, or 7-membered nitrogen containing ring;
R17 and R18 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, hetaryl, hetaryl(C1-6alkyl)- and aryl(C1-6alkyl)-, or R17 and R18,together with the nitrogen to which they are bonded, form a 5-, 6-, or 7-membered nitrogen containing ring;
and R17 and R18 are each optionally substituted by one or two groups independently selected from halo, C1-6alkyl, and C3-7cycloalkyl, C1-6haloalkyl;
R12 is selected from hydrogen, pyridine, C1-6alkyl, C1-6alkoxy, halo, aryl, aryl(C1-6alkyl)-, C1-6haloalkoxy, and C1-6haloalkyl;
R13 is selected from hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, halo, aryl, aryl(C1-6alkyl)-, C1-6haloalkoxy, and C1-6haloalkyl;
R1 and R2 are independently selected from hydrogen and C1-4 alkyl with the proviso that the total number of carbon atoms in R1 and R2 is not more than 4;
one of R1a and R2a is selected from hydrogen and C1-4alkyl, and the other of R1a and R2a represents hydrogen or C1-4alkyl;
m is an integer of from 1 to 3;
n is an integer of from 1 to 4; and
p is zero or an integer of from 1 to 3;
and represents a single or double bond.
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Accused Products
Abstract
The present invention relates to novel compounds of formula (I),
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Citations
23 Claims
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1. A compound of formula (I):
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or a salt, solvate, or physiologically functional derivative thereof, wherein;
Ar1 is a group selected from wherein R4 represents hydrogen, halogen, —
(CH2)qOR7, —
NR7C(O)R8, —
NR7SO2R8, —
SO2NR7R8, —
NR7R8, —
OC(O)R9 or OC(O)NR7R8, and R3 represents hydrogen, halogen or C1-4 alkyl;
or R4 represents —
NHR10 and R3 and —
NHR10 together form a 5- or 6-membered heterocyclic ring;
R5 represents hydrogen, halogen, —
OR7 or —
NR7R8;
R6 represents hydrogen, halogen, haloC1-4alkyl, —
OR7, —
NR7R8, —
OC(O)R9 or OC(O)NR7R8;
R7 and R8 each independently represents hydrogen or C1-4 alkyl, or in the groups —
NR7R8, —
SO2NR7R8 and —
OC(O)NR7R8, R7 and R8 independently represent hydrogen or C1-4 alkyl or together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered nitrogen-containing ring,R9 represents an aryl group which may be unsubstituted or substituted by one or more substituents selected from halogen, C1-4 alkyl, hydroxyl, C1-4 alkoxy or halo C1-4 alkyl; and
q is zero or an integer from 1 to 4;
Ar2 is a group;
whereinR11 is selected from hydrogen, C1-6alkyl, hydroxy, C1-6alkoxy, cyano, nitro, halo, C1-6haloalkyl, XCO2R16, —
XC(O)NR15R16, —
XNR14C(O)R15, —
XNR14C(O)NR15R16, —
XNR14C(O)NC(O)NR15R16, —
XNR14SO2R15, —
XSO2NR17R18, XSR14, XSOR14, XSO2R14, —
XNR15R16, —
XNR14C(O)OR15, or XNR14SO2NR15R16, or R11 is selected from —
X-aryl, —
X-hetaryl, or —
X-(aryloxy), each optionally substituted by 1 or 2 groups independently selected from hydroxy, C1-6alkoxy, halo, C1-6alkyl, C1-6haloalkyl, cyano, nitro, CONR15R16, —
NR14C(O)R15, SR14, SOR14, —
SO2R14, —
SO2NR17R18, —
CO2R16, —
NR15R16, or hetaryl optionally substituted by 1 or 2 groups independently selected from hydroxy, C1-6alkoxy, halo, C1-6alkyl, or C1-6haloalkyl;
X is —
(CH2)r—
or C2-6 alkenylene;
r is an integer from 0 to 6;
R14 and R15 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, hetaryl, hetaryl(C1-6alkyl)- and aryl(C1-6alkyl)- and R14 and R15 are each independently optionally substituted by 1 or 2 groups independently selected from halo, C1-6alkyl, C3-7 cycloalkyl, C1-6 alkoxy, C1-6haloalkyl, —
NHC(O)(C1-6alkyl), —
SO2(C1-6alkyl), —
SO2(aryl), —
CO2H, and —
CO2(C1-4alkyl), —
NH2, —
NH(C1-6alkyl), aryl(C1-6alkyl)-, aryl(C2-6alkenyl)-, aryl(C2-6alkynyl)-, hetaryl(C1-6alkyl)-, —
NHSO2aryl, —
NH(hetarylC1-6alkyl), —
NHSO2hetaryl, —
NHSO2(C1-6alkyl), —
NHC(O)aryl, or —
NHC(O)hetaryl;
or R14 and R15, together with the nitrogen atom to which they are bonded, form a 5-, 6- or 7-membered nitrogen—
containing ring;
or where R11 is —
XNR14C(O)NR15R16, R14 and R15 may, together with the —
NC(O)N—
portion of the group R1 to which they are bonded, form a saturated or unsaturated ringor where R11 is —
XNR14C(O)OR15, R14 and R15 may, together with the —
NC(O)O—
portion of the group R11 to which they are bonded, form a saturated or unsaturated ring;
R16 is selected from hydrogen, C1-6alkyl and C3-7 cycloalkyl;
or where R11 is —
XC(O)NR15R16 or —
XNR14C(O)NR15R16, R15 and R16 may, together with the nitrogen to which they are bonded, form a 5-, 6-, or 7-membered nitrogen containing ring;
R17 and R18 are independently selected from hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, hetaryl, hetaryl(C1-6alkyl)- and aryl(C1-6alkyl)-, or R17 and R18,together with the nitrogen to which they are bonded, form a 5-, 6-, or 7-membered nitrogen containing ring;
and R17 and R18 are each optionally substituted by one or two groups independently selected from halo, C1-6alkyl, and C3-7cycloalkyl, C1-6haloalkyl;
R12 is selected from hydrogen, pyridine, C1-6alkyl, C1-6alkoxy, halo, aryl, aryl(C1-6alkyl)-, C1-6haloalkoxy, and C1-6haloalkyl;
R13 is selected from hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, halo, aryl, aryl(C1-6alkyl)-, C1-6haloalkoxy, and C1-6haloalkyl;
R1 and R2 are independently selected from hydrogen and C1-4 alkyl with the proviso that the total number of carbon atoms in R1 and R2 is not more than 4;
one of R1a and R2a is selected from hydrogen and C1-4alkyl, and the other of R1a and R2a represents hydrogen or C1-4alkyl;
m is an integer of from 1 to 3;
n is an integer of from 1 to 4; and
p is zero or an integer of from 1 to 3;
and represents a single or double bond. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23)
and in the group Ar1, either;
R4 represents halogen, —
(CH2)qOR7, —
NR7C(O)R8, —
NR7SO2R8, —
SO2NR7R8, —
NR7R8,—
OC(O)R9 or OC(O)NR7R8, and R3 represents hydrogen or C1-4 alkyl;
or;
R4 represents —
NHR10 and R3 and —
NHR10 together form a 5- or 6-membered heterocyclic ring;
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3. A compound of formula (I) according to claim 1 wherein the group Ar1 is selected from groups (a) and (b) as defined in claim 1.
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4. A compound of formula (I) according to claim 1 wherein, in the group Ar2, R11 is selected from hydrogen, C1-4alkyl, hydroxy, halo, —
- NR14C(O)NR15R16, —
NR14SO2R15 and XSO2NR17R18.
- NR14C(O)NR15R16, —
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5. A compound of formula (I) according to claim 1 wherein, in the group Ar2, R11 is selected from cyano, —
- CONR15R16, SR14, SOR14 and SO2R14.
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6. A compound of formula (I) according to claim 1 wherein R12 and R13 each represent hydrogen.
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7. A compound of formula (I) according to claim 1 wherein R11 represents hydrogen and R12 and R13 each represent halogen or C1-6alkyl.
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8. A compound of formula (I) according to claim 1 wherein R1 and R2 are both hydrogen.
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9. A compound of formula (I) according to claim 1 wherein each of m and n is independently 1 or 2, and p is zero or 1.
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10. A compound of formula (I) according to claim 1 selected from:
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4-((1R)-2-{[2-((3R)-3-{[(2,6-Dichlorobenzyl)oxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
4-{(1R)-2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol;
4-{(1R)-2-[(2-{(3S)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol;
2-(Hydroxymethyl)-4-{((1R)-1-hydroxy-2-[(2-{(3R)-3-[(□
yridine-3-ylmethoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]ethyl}phenol;
4-((1R)-2-{[2-((3R)-3-{[(6-Chloropyridin-3-yl)methoxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
4-((1R)-2-{[2-((3R)-3-{[(2,6-Dichloropyridin-3-yl)methoxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
4-{(1R)-2-[(2-{2-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol;
4-((1R)-2-{[2-((3R)-3-{[(5-Bromopyridin-3-yl)methoxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
3-[({(2R)-7-[2-({(2R)-2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]-2,3-dihydro-1,4-benzodioxin-2-yl}methoxy)methyl]benzonitrile;
3-[({(2R)-7-[2-({(2R)-2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]-2,3-dihydro-1,4-benzodioxin-2-yl}methoxy)methyl]benzamide;
4-[(1R)-2-({2-[(3R)-3-({[3-(Cyclopentylthio)benzyl]oxy}methyl)-2,3-dihydro-1,4-benzodioxin-6-yl]ethyl}amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;
4-[(1R)-2-({2-[(3R)-3-([3-(Cyclopentylsulfonyl)benzyl]oxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]ethyl}amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;
2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-{(3R)-3-[({5-[4-(methylsulfinyl)phenyl]□
yridine-3-yl}methoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]ethyl}phenol;
N-{3-[({(2R)-7-[2-({(2R)-2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]-2,3-dihydro-1,4-benzodioxin-2-yl}methoxy)methyl]phenyl}urea;
4-((1R)-2-{[2-((3R)-3-{[(4-Chlorobenzyl)oxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
4-((1R)-2-{[2-((3R)-3-{[(4-Fluorobenzyl)oxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
4-((1R)-2-{[2-((3R)-3-{[(3,5-Dimethylbenzyl)oxy]methyl}-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-{(3R)-3-[(1-phenylethoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]ethyl}phenol;
2-(Hydroxymethyl)-4-[(1R)-1-hydroxy-2-({2-[(3R)-3-({[3-(methylsulfonyl)benzyl]oxy}methyl)-2,3-dihydro-1,4-benzodioxin-6-yl]ethyl}amino)ethyl]phenol;
4-((1R)-2-{[2-((3R)-3-([3-(2,6-Dichlorophenyl)propoxy]methyl,-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]amino}-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
3-[({(2R)-7-[2-({(2R)-2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]-2,3-dihydro-1,4-benzodioxin-2-yl}methoxy)methyl]benzenesulfonamide;
6-{2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)[lyridine-3-ol;
N-(5-{(1R)-2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-hydroxyphenyl)methanesulfonamide;
4-{(1R)-2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-fluorophenol;
4-{(1R)-2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-3-methylphenol;
(1R)-1-(4-Amino-3,5-dichlorophenyl)-2-[(2-(3R)-3-[(benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]ethanol;
5-{(1R)-2-[(2-{(3R)-3-[(Benzyloxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl}ethyl)amino]-1-hydroxyethyl}-2-hydroxyphenylformamide;
or a salt, solvate or physiologically functional derivative thereof.
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11. A method for the prophylaxis or treatment of a clinical condition in a mammal for which a selective β
- 2-adrenoreceptor agonist is indicated, which comprises administering a therapeutically effective amount of a compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof.
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13. A pharmaceutical formulation comprising a compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and a pharmaceutically acceptable carrier or excipient, and optionally one or more other therapeutic ingredients.
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15. A process for the preparation of a compound of formula (I), according to claim 1, or a salt, solvate, or physiologically functional derivative thereof, which comprises:
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deprotecting a protected intermediate of formula (II)
or a salt or solvate thereof, wherein R1, R2, R1a, R2a, m, n, p and are as defined for the compound of formula (I), Ar1a represents an optionally protected form of Ar1;
Ar2a represents an optionally protected form of Ar2 and R23 and R24 are each independently either hydrogen or a protecting group, provided that the compound of formula (II) contains at least one protecting group;
wherein said process is odtionallv followed by one or more of the following steps in any order selected from the group consisting of;
(i) removing any protecting groups;
(ii) separating an enantiomer from a mixture of enantiomers; and
(iii) converting the product to a corresponding salt, solvate, or physiologically functional derivative thereof.
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16. A compound of formula (I) as defined in claim 1, or a salt, solvate or physiologically functional derivative thereof, wherein R11 is —
- XNR14C(O)NR15R16, and wherein R14 and R15 form a 5-, 6-, or 7-membered ring.
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17. A compound of formula (I) as defined in claim 16, or a salt, solvate or physiologically functional derivative thereof, wherein the 5-, 6-, or 7-membered ring is an imidazolidine ring.
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18. A compound of formula (I) as defined in claim 17, or a salt, solvate or physiologically functional derivative thereof, wherein the imidazolidine ring is imidazolidine-2,4-dione.
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19. A compound of formula (I) as defined in claim 1, or a salt, solvate or physiologically functional derivative thereof, where R11 is —
- XNR14C(O)OR15, and wherein R14 and R15 form a 5-, 6-, or 7-membered ring.
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20. A compound of formula (I) as defined in claim 19, or a salt, solvate or physiologically functional derivative thereof, wherein the 5-, 6-, or 7-membered ring is an oxazolidine ring.
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21. A compound of formula (I) as defined in claim 20, or a salt, solvate or physiologically functional derivative thereof, wherein the oxazolidine ring is oxazolidine-2,4-dione.
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22. A method according to claim 11, wherein the mammal is a human.
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23. A process for the preparation of a compound of formula (I), according to claim 1, or a salt, solvate, or physiologically functional derivative thereof, which comprises:
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alkylating an amine of formula
wherein Ar1a, R23 and R24 are as defined for formula (II) with a compound of formula (XV);
wherein , Ar2, R1, R2, R1a, R2a, m, n and p are as defined for the compound of formula (II) and L is a leaving group as defined for formula (IX);
wherein said process is optionally followed by one or more of the following steps in any order selected from the group consisting of;
(i) removing any protecting groups;
(ii) separating an enantiomer from a mixture of enantiomers; and
(iii) converting the product to a corresponding salt, solvate, or physiologically functional derivative thereof.
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12. (canceled)
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14. (canceled)
Specification