Methods and compositions for treating a disease condition in a subject

• US 20060206149A1
• Filed: 01/30/2006
• Published: 09/14/2006
• Est. Priority Date: 02/04/2005
• Status: Active Grant

• Current Assignee: Palo Alto Investors
• Original Assignee: Palo Alto Investors
• Inventors: Yun, Anthony Joonkyoo
• Granted Patent: US 9,833,618 B2
• Time in Patent Office: Days
• US Class Current: 607/3
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 2/002 in combination with another treatment

Abstract

Methods for treating a disease condition in a subject are provided. The subject methods include selectively modulating at least one biological activity of advential tissue in a manner effective to treat the disease condition. Also provided are compositions, kits and systems for use in practicing the subject methods.

Claims

1. A method of treating a subject for a disease condition, said method comprising:

selectively modulating at least one biological activity of adventitial tissue of said subject in a manner effective to treat the disease condition.

2. The method according to claim 1, wherein said modulating is by administering a pharmacological agent to said subject.

3. The method according to claim 2, wherein said modulating is by applying electrical stimulation to said subject.

4. The method according to claim 1, wherein said biological activity is Inflammatory activity.

5. The method according to claim 1, wherein said biological activity is autonomic activity.

6. The method according to claim 1, wherein said disease condition is a vascular disease condition.

7. The method according to claim 6, wherein said vascular disease condition is atherosclerosis.

8. The method according to claim 6, wherein said vascular disease condition involves renal function.

9. The method according to claim 6, wherein said vascular disease condition involves stenosis of a vessel.

10. The method according to claim 6, wherein said vascular disease condition is vasculitis of any type.

11. The method according to claim 6, wherein said vascular disease condition is diabetes mellitus.

12. The method according to claim 6, wherein said vascular disease condition is stroke.

13. The method according to claim 7, wherein said method comprises modulating the sympathetic/parasympatheuc bias of said adventitial tissue of said subject.

14. The method of claim 1, wherein said method involves direct application of a stimulus to the adventitia of a target region of a vessel.

15. The method of claim 1, wherein said method involves direct application of a stimulus to the adventitia of vessels adjoining a target region of a vessel.

16. The method of claim 1, wherein said method involves direct application of a stimulus to the autonomic nerves supplying the adventitia of the target vessel/s.

17. The method of claim 1, wherein said method involves direct application to the baroreceptors influencing the biology of the adventitia of the target vessel/s.

18. The method of claim 1, wherein said method involves direct application of a stimulus to the chemoreceptors Influencing the biology of the adventitia of the target vessel/s.

19. The method of claim 1, wherein said method involves direct application of a stimulus to the volume receptors influencing the biology of the adventitia of the target vessel/s.

20. The method of claim 1, wherein said method involves direct application of a stimulus to adjacent readily accessible tissue structures physically linked to the adventitia of the target vessel/s.

21. The method of claim 1, wherein said method Involves systemic administration of pharmacologically active agent targeted to specific receptors in the adventitia.

22. An algorithm recorded on a computer-readable medium for administering a stimulus to said subject in accordance with method of claim 1.

23. A system comprising:

(a) an algorithm recorded on a computer-readable medium for administering a stimulus to a subject according to a method of claim 1;

and

(b) a stimulus producing component.

24. The system according to claim 23, wherein said stimulus producing component is a pharmacological agent delivery device.

25. The system according to claim 23, wherein said stimulus producing component is an electrical energy applying device.

26-40. -40. (canceled)