Methods and apparatus for treating acute myocardial infarction

• US 20060206150A1
• Filed: 03/06/2006
• Published: 09/14/2006
• Est. Priority Date: 04/08/2002
• Status: Abandoned Application

• Current Assignee: Ardian, Inc. (Medtronic Plc)
• Original Assignee: Ardian, Inc. (Medtronic Plc)
• Inventors: Levin, Howard R., Demarais, Denise, Gelfand, Mark, Gifford, Hanson III, Sutton, Douglas, Deem, Mark
• Application Number:
  US11/368,971
• Publication Number:
  US 20060206150A1
• Time in Patent Office: Days
• US Class Current: 607/3
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Claims

1. A method for treating acute myocardial infarction, the method comprising:

modulating a function of a neural fiber that contributes to renal function of a kidney of a patient,

wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber.

2. The method of claim 1, wherein modulating the function of the neural fiber further comprises modulating the function of the neural fiber via an electric field.

3. The method of claim 2, wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a pulsed electric field.

4. The method of claim 2, wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a stimulation electric field.

5. The method of claim 1, wherein modulating the function of the neural fiber further comprises delivering a neuromodulatory agent to the neural fiber.

6. The method of claim 1, wherein modulating the function of the neural fiber further comprises at least partially denervating the kidney.

7. The method of claim 1, wherein modulating the function of the neural fiber further comprises inducing an effect in the neural fiber chosen from the group consisting of irreversible electroporation, electrofusion, necrosis, apoptosis, gene expression alteration, cytokine up-regulation alteration, and combinations thereof.

8. The method of claim 1, wherein modulating the function of the neural fiber further comprises thermally modulating the function of the neural fiber.

9. The method of claim 1, wherein modulating the function of the neural fiber further comprises modulating the function of the neural fiber with high frequency ultrasound.

10. A method for treating acute myocardial infarction, the method comprising:

modulating a function of a neural fiber that contributes to renal function of a kidney of a patient,

wherein modulating the function of the neural fiber further comprises modulating the function via a percutaneous approach.

11. The method of claim 10, wherein modulating the function via a percutaneous approach further comprises modulating the function via a laparoscopic approach.

12. The method of claim 10, wherein modulating the function via a percutaneous approach further comprises modulating the function via an endoluminal approach.

13. The method of claim 10, wherein modulating the function of the neural fiber further comprises modulating the function of the neural fiber via an electric field.

14. The method of claim 13, wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a pulsed electric field.

15. The method of claim 13, wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a stimulation electric field.

16. The method of claim 10, wherein modulating the function of the neural fiber further comprises delivering a neuromodulatory agent to the neural fiber.

17. The method of claim 10, wherein modulating the function of the neural fiber further comprises at least partially denervating the kidney.

18. The method of claim 10, wherein modulating the function of the neural fiber further comprises inducing an effect in the neural fiber chosen from the group consisting of irreversible electroporation, electrofusion, necrosis, apoptosis, gene expression alteration, cytokine up-regulation alteration, and combinations thereof.

19. The method of claim 10, wherein modulating the function of the neural fiber further comprises thermally modulating the function of the neural fiber.

20. The method of claim 10, wherein modulating the function of the neural fiber further comprises modulating the function of the neural fiber with high frequency ultrasound.