Miniaturized high-density multichannel electrode array for long-term neuronal recordings
First Claim
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1. An intelligent brain pacemaker for a mammal having a cranial nerve not associated with an autonomic function comprising:
- (a) a multichannel microwire electrode array for acquiring neural signals from a plurality of single neurons comprising;
(i) a plurality of microwire electrodes;
(ii) one or more printed circuit boards in electrical connection with the microwire electrodes comprising;
(1) a plurality of conductive traces spaced apart about 0.015 inches (center to center) or less; and
(2) a plurality of conductive pads in communication with the conductive traces; and
(iii) one or more connectors in electrical connection with the conductive pads and having contacts spaced about apart 0.030 inches (center to center) or less;
(b) a seizure detector adapted to detect seizure-related brain activity of a mammal in real-time, the seizure detector being electrically connected to the multichannel microwire electrode array;
(c) one or more nerve stimulators adapted to provide electrical stimulation to a mammal'"'"'s cranial nerve not associated with an autonomic function, to terminate or ameliorate the seizure, the one or more nerve simulators being electrically connected to the seizure detector; and
(d) a power source for providing power to the intelligent brain pacemaker.
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Abstract
A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array are disclosed, including an intelligent brain pacemaker and a closed loop brain machine interface.
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Citations
11 Claims
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1. An intelligent brain pacemaker for a mammal having a cranial nerve not associated with an autonomic function comprising:
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(a) a multichannel microwire electrode array for acquiring neural signals from a plurality of single neurons comprising;
(i) a plurality of microwire electrodes;
(ii) one or more printed circuit boards in electrical connection with the microwire electrodes comprising;
(1) a plurality of conductive traces spaced apart about 0.015 inches (center to center) or less; and
(2) a plurality of conductive pads in communication with the conductive traces; and
(iii) one or more connectors in electrical connection with the conductive pads and having contacts spaced about apart 0.030 inches (center to center) or less;
(b) a seizure detector adapted to detect seizure-related brain activity of a mammal in real-time, the seizure detector being electrically connected to the multichannel microwire electrode array;
(c) one or more nerve stimulators adapted to provide electrical stimulation to a mammal'"'"'s cranial nerve not associated with an autonomic function, to terminate or ameliorate the seizure, the one or more nerve simulators being electrically connected to the seizure detector; and
(d) a power source for providing power to the intelligent brain pacemaker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification