Polymer adhesive splicing of water-soluble, orally ingestible thin film webs

• US 20060207721A1
• Filed: 03/17/2005
• Published: 09/21/2006
• Est. Priority Date: 03/17/2005
• Status: Abandoned Application

• Current Assignee: Christopher E. Fankhauser, Greg Slominski
• Original Assignee: Christopher E. Fankhauser, Greg Slominski
• Inventors: Fankhauser, Christopher E., Slominski, Greg
• Application Number:
  US11/083,162
• Publication Number:
  US 20060207721A1
• Time in Patent Office: Days
• US Class Current: 156/326
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: B65H 19/1842 standing splicing, i.e. the expiring web being stationary during splicing contact
• CPC Class Codes: B65H 29/62 diverting faulty articles from the main streams control devices detecting faulty articles B65H43/04

Abstract

A method is provided to splice and/or repair films. The method comprises: a) applying a splicing composition to a first water-soluble, orally-ingestible film, a second water-soluble, orally-ingestible film or to both films; b) overlapping the first water-soluble, orally-ingestible film on the second water-soluble, orally-ingestible film to form a splice between the first water-soluble, orally-ingestible film and the second water-soluble, orally-ingestible film; and c) allowing the splice to dry or cure, wherein the splicing composition comprises at least one animal-consumable solvent and, optionally, at least one orally-ingestible polymer.

Claims

1. A method comprising:

a) applying a splicing composition to a first water-soluble, orally-ingestible film, a second water-soluble, orally-ingestible film or to both films;

b) overlapping the first film on the second film to form a splice between the first film and the second film; and

c) allowing the splice to dry or cure,

wherein the splicing composition comprises at least one animal-consumable solvent and, optionally, at least one orally-ingestible polymer.

2. The method of claim 1, wherein the first water-soluble, orally-ingestible film is on a first roll and the second water-soluble, orally-ingestible film is on a second roll.

3. The method of claim 1, wherein the first water-soluble, orally-ingestible film and the water-soluble, orally-ingestible second film are parts of the same film.

4. The method of claim 1, wherein no tape is used to form the splice.

5. The method of claim 1, wherein the at least one orally-ingestible polymer is present in the splicing composition.

6. The method of claim 1, wherein the at least one orally-ingestible polymer is present in the splicing composition in an amount from greater than 0-30% by weight of the splicing composition.

7. The method of claim 1, wherein the at least one animal-consumable solvent is at least one of water, ethanol, acetone, 1-propanol and/or 2-propanol.

8. The method of claim 5, wherein the at least one orally-ingestible polymer is at least one of hydroxypropyl cellulose, hypromellose, hydroxypropyl methyl cellulose, polyvinyl alcohol, hydroxyl ethyl cellulose, pullulan, polyvinyl pyrrolidone, carboxymethyl cellulose, sodium alginate, polyethylene glycol, xanthan gum tragancanth gum, guar gum, acacia gum, arabic gum, starch, gelatin, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl copolymers, ethyl cellulose, hydroxypropyl ethyl cellulose, cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, poly(glycolic acid), poly(lactic acid), polydioxanoes, polyoxalates, poly(α

-esters), polyanhydrides, polyacetates, polycaprolactones, poly(orthoesters), polyamino acids, polyaminocarbonates, polyurethanes, polycarbonates, polyamides, poly(alkyl cyanoacrylates), stereopolymers of L- and D-lactic acid, copolymers of bis(p-carboxyphenoxy) propane acid and sebacic acid, sebacic acid copolymers, copolymers of caprolactone, poly(lactic acid)/poly(glycolic acid)/polyethyleneglycol copolymers, copolymers of polyurethane and poly(lactic acid), copolymers of polyurethane and poly(lactic acid), copolymers of α

-amino acids, copolymers of α

-amino acids and caproic acid, copolymers of α

-benzyl glutamate and polyethylene glycol, copolymers of succinate and poly(glycols), polyphosphazene, polyhydroxy-alkanoates, a lactide/glycolide co-polymer and/or polyanhydrides.

9. The method of claim 1, wherein the splicing composition is applied to a film in an amount from to 10-80% by weight of the film area to which the splicing composition is applied (wt./wt.)

10. The method of claim 1, wherein the animal-consumable solvent comprises water.

11. The method of claim 1, wherein the animal-consumable solvent comprises a mixture of water and ethanol.

12. The method of claim 1, wherein the animal-consumable solvent comprises a mixture of water and ethanol, wherein the water is present in the animal-consumable solvent in an amount from 10-90% by weight of water.

13. The method of claim 1, wherein the first water-soluble, orally-ingestible film overlaps the second water-soluble, orally-ingestible film in an amount from 10-50 mm.