Ocular delivery of polymeric delivery formulations
First Claim
1. A flowable composition suitable for use as a controlled release implant, the composition comprising:
- (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid;
(b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and
(c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble;
wherein the composition is suitable for ocular delivery.
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Accused Products
Abstract
The present invention provides a flowable composition suitable for use as a controlled release implant. The flowable composition can be administered into the ocular region of a mammal. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides methods of medical treatment that include administering the flowable composition into the ocular region of a mammal.
298 Citations
110 Claims
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1. A flowable composition suitable for use as a controlled release implant, the composition comprising:
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(a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid;
(b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and
(c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble;
wherein the composition is suitable for ocular delivery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 92, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110)
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81. An implant comprising:
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(a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid;
(b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and
(c) a biocompatible organic liquid at standard temperature and pressure, in which the thermoplastic polymer is soluble;
wherein the implant is located in the ocular region of a mammal and the implant has a solid or gelatinous microporous matrix, the matrix being a core surrounded by a skin and wherein the implant is surrounded by body tissue. - View Dependent Claims (82, 83, 84, 85, 86, 87)
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88. An implant comprising:
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(a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; and
(b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof;
wherein the implant is located in the ocular region of a mammal and the implant has a solid or gelatinous microporous matrix, the matrix being a core surrounded by a skin and wherein the implant is surrounded by body tissue. - View Dependent Claims (89, 90, 91)
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93. A biological agent kit suitable for in situ formation of a biodegradable implant in an ocular region, the kit comprising:
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(a) a first container comprising a flowable composition suitable for delivery into an ocular region, the composition comprising;
(i) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; and
(ii) a biocompatible organic liquid at standard temperature and pressure, in which the thermoplastic polymer is soluble;
(b) a second container comprising a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof. - View Dependent Claims (94, 95, 96, 97)
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Specification