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Hyaluronan synthases and methods of making and using same

  • US 20060211104A1
  • Filed: 05/31/2006
  • Published: 09/21/2006
  • Est. Priority Date: 12/03/2001
  • Status: Abandoned Application
First Claim
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1. A recombinant host cell comprising at least one expression construct comprising a hyaluronan synthase gene encoding a functionally active hyaluronan synthase such that the recombinant host cell is capable of producing hyaluronic acid, the functionally active hyaluronan synthase having an altered enzymatic activity as compared to a corresponding functionally active native hyaluronan synthase, and wherein the functionally active hyaluronan synthase has at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase, and wherein the at least one modified amino acid residue is a cysteine modified to an alanine or a serine residue.

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