Noninvasive analyzer sample probe interface method and apparatus
First Claim
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1. An adaptive mount for coupling a sample probe to a sample site of a tissue, comprising:
- a first alignment piece; and
a second alignment piece;
wherein both said first alignment piece and said second alignment piece replaceably abut said tissue, wherein said first alignment piece and said second alignment piece cooperate to position said sample probe relative to said sample site during use; and
wherein said adaptive mount adapts said position of said sample probe relative to said tissue as either distance between, or orientation of, said first alignment piece and said second alignment piece change due to state change of said tissue.
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Abstract
The invention provides an adaptive mount for use in coupling a noninvasive analyte property analyzer to a living tissue sample site. The adaptive mount increases precision and accuracy of sampling by relieving stress and strain on a sample prior to and/or during sampling, which results in noninvasive analyte property estimations with corresponding performance enhancement.
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Citations
19 Claims
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1. An adaptive mount for coupling a sample probe to a sample site of a tissue, comprising:
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a first alignment piece; and
a second alignment piece;
wherein both said first alignment piece and said second alignment piece replaceably abut said tissue, wherein said first alignment piece and said second alignment piece cooperate to position said sample probe relative to said sample site during use; and
wherein said adaptive mount adapts said position of said sample probe relative to said tissue as either distance between, or orientation of, said first alignment piece and said second alignment piece change due to state change of said tissue. - View Dependent Claims (2, 3, 4)
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5. An apparatus for noninvasively measuring an analyte property at a sample site of tissue, comprising:
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a base module;
a sample module coupled to said base module, said sample module having a tip; and
an adaptive mount replaceably coupled to said sample module, wherein said adaptive mount positions with freedom of movement along at least one of an x-axis and a y-axis said sample probe tip relative to a sample site of said tissue as said tissue changes state in terms of any of;
elongation;
expansion;
contraction; and
twist orientation, wherein said x-axis is along the length of a body part and said y-axis is across said body part. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A method for noninvasive analysis of a tissue sample glucose concentration, comprising the step of:
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moving a sample probe tip into proximate contact with a tissue sample site, with freedom of movement along at least one of an x-axis and a y-axis relative to said sample site as tissue at said sample site changes state in terms of any of;
elongation;
expansion;
contraction; and
twist orientation;
wherein said x-axis is along the length of a body part and said y- axis is across said body part;
wherein said means for moving are operatively coupled to an analyzer;
acquiring with said analyzer a noninvasive near-infrared spectrum of said tissue sample; and
determining glucose concentration representative of said tissue sample by applying a multivariate analysis to said noninvasive spectrum.
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14. An apparatus for to coupling a sample probe to a sample site of tissue, comprising:
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a mount in proximate contact with said tissue during use;
wherein said mount is used in conjunction with a noninvasive analyzer having a sample probe;
andwherein during use said mount adapts position of said sample probe relative to said tissue as said tissue changes state in terms of any of;
response to a stress;
an elongation;
a contraction; and
a twist. - View Dependent Claims (15)
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16. An adaptive mount used to couple a sample probe to a sample site of a tissue, comprising:
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a first alignment piece having a contact surface, at least a portion of said contact surface being in contact with a surface proximate said tissue during use; and
a second alignment piece having a tissue side surface, at least a portion of said tissue side surface being in contact with said surface proximate said tissue during use;
wherein said first alignment piece and said second alignment piece move with said tissue as said tissue changes state in terms of any of expansion, contraction, and twist;
wherein said first alignment piece and said second alignment piece cooperatively position said sample probe of an analyzer to said sample site; and
wherein said sample site varies with said change in tissue state. - View Dependent Claims (17, 18, 19)
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Specification