Methods and apparatus for treating end-stage renal disease
First Claim
1. A method for treating end-stage renal disease, the method comprising:
- modulating a function of a neural fiber that contributes to renal function of a kidney of a patient, wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber.
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Abstract
Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
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Citations
20 Claims
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1. A method for treating end-stage renal disease, the method comprising:
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modulating a function of a neural fiber that contributes to renal function of a kidney of a patient, wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating end-stage renal disease, the method comprising:
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modulating a function of a neural fiber that contributes to renal function of a kidney of a patient, wherein modulating the function of the neural fiber further comprises modulating the function via a percutaneous approach. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification