Multiwell sample plate with integrated impedance electrodes and connection scheme
First Claim
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1. A multiwell impedance measurement device comprising:
- A. a plurality of chambers for containing separated samples in a planar array configuration, Said chambers having a bottom surface and said chambers being formed from an upper plate containing a plurality of through holes and a bottom plate, Said bottom plate having a top surface and a bottom surface, Said upper plate having a top surface and a bottom surface Said top surface of said bottom plate being sealingly affixed to said bottom surface of said upper plate. B. A plurality of functionally equivalent impedance measuring electrodes lying flat on said bottom surface of each of said plurality of chambers and on said top surface of said bottom plate, said electrodes exposed to said samples, wherein each of said electrodes is electrically insulated from each of the other electrodes in the device, said electrodes having a top surface and a bottom surface. C. Connection means for making electrical contact with each of said electrodes from said bottom surface of said bottom plate.
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Abstract
As disclosed within, the present device is directed to a multi-well sample module having integrated impedance measuring electrodes (which allow for the generation of an electric field within each well and the measuring of the change in impedance of each of the well'"'"'s contents) and an electrical connection scheme allowing simultaneous measurement of each well'"'"'s change in impedance.
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Citations
104 Claims
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1. A multiwell impedance measurement device comprising:
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A. a plurality of chambers for containing separated samples in a planar array configuration, Said chambers having a bottom surface and said chambers being formed from an upper plate containing a plurality of through holes and a bottom plate, Said bottom plate having a top surface and a bottom surface, Said upper plate having a top surface and a bottom surface Said top surface of said bottom plate being sealingly affixed to said bottom surface of said upper plate. B. A plurality of functionally equivalent impedance measuring electrodes lying flat on said bottom surface of each of said plurality of chambers and on said top surface of said bottom plate, said electrodes exposed to said samples, wherein each of said electrodes is electrically insulated from each of the other electrodes in the device, said electrodes having a top surface and a bottom surface. C. Connection means for making electrical contact with each of said electrodes from said bottom surface of said bottom plate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A multiwell impedance measurement device comprising:
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A. a plurality of chambers for containing separated samples in a planar array configuration, Said chambers having a bottom surface and said chambers being formed from a plate containing a plurality of holes extending partially through said plate. B. A plurality of functionally equivalent impedance measuring electrodes lying flat on said bottom surface of each of said plurality of chambers, said electrodes exposed to said samples, wherein each of said electrodes is electrically insulated from each of the other electrodes in the device, said electrodes having a top surface and a bottom surface, said plate being formed around said electrodes. C. Connection means for making electrical contact with said electrodes from said bottom surface of said plate. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A multiwell impedance measurement device comprising:
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A. a plurality of chambers for containing separated samples in a planar array configuration, Said chambers having a bottom surface and said chambers being formed from an upper plate containing a plurality of through holes and a bottom plate, Said bottom plate having a top surface and a bottom surface, Said upper plate having a top surface and a bottom surface Said top surface of said bottom plate being sealingly affixed to said bottom surface of said upper plate. B. A plurality of functionally equivalent impedance measuring electrodes lying flat on said bottom of each of said plurality of chambers and on said top surface of said bottom plate, said electrodes exposed to said samples, wherein each of said electrodes is electrically insulated from each of the other electrodes in the device, said electrodes having a top surface and a bottom surface. C. Connection means for making electrical contact with each of said electrodes from said bottom surface of said bottom plate. D. A means for instrument readable plate identification. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104)
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Specification