Delivery of compounds for the treatment of parkinson's through an inhalation route
First Claim
1. A composition for delivery of benzotropine consisting of a condensation aerosol a) formed by volatilizing a thin layer of benzotropine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of benzotropine and condensing the heated vapor of benzotropine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% benzotropine degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of antiparkinsons drugs through an inhalation route. In a method aspect of the present invention, an antiparkinsons drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiparkinsons drug on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering an antiparkinsons drug through an inhalation route is provided which comprises: a) a thin coating of a an antiparkinsons drug composition; and, b) a device for dispending said thin coating as a condensation aerosol.
141 Citations
34 Claims
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1. A composition for delivery of benzotropine consisting of a condensation aerosol
a) formed by volatilizing a thin layer of benzotropine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of benzotropine and condensing the heated vapor of benzotropine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% benzotropine degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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5. A composition for delivery of pergolide consisting of a condensation aerosol
a) formed by volatilizing a thin layer of pergolide on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of pergolide and condensing the heated vapor of pergolide to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% pergolide degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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9. A composition for delivery of amantadine consisting of a condensation aerosol
a) formed by volatilizing a thin layer of amantadine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of amantadine and condensing the heated vapor of amantadine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% amantadine degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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13. A composition for delivery of deprenyl consisting of a condensation aerosol
a) formed by volatilizing a thin layer of deprenyl on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of deprenyl and condensing the heated vapor of deprenyl to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% deprenyl degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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17. A composition for delivery of ropinerole consisting of a condensation aerosol
a) formed by volatilizing a thin layer of ropinerole on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of ropinerole and condensing the heated vapor of ropinerole to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% ropinerole degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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20. A method of producing benzotropine in an aerosol form comprising:
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a. heating a thin layer of benzotropine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the benzotropine to form a heated vapor of the benzotropine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the benzotropine comprising less than 5% benzotropine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (21, 22)
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23. A method of producing pergolide in an aerosol form comprising:
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a. heating a thin layer of pergolide on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the pergolide to form a heated vapor of the pergolide, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the pergolide comprising less than 5% pergolide degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (24, 25)
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26. A method of producing amantadine in an aerosol form comprising:
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a. heating a thin layer of amantadine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the amantadine to form a heated vapor of the amantadine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the amantadine comprising less than 5% amantadine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (27, 28)
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29. A method of producing deprenyl in an aerosol form comprising:
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a. heating a thin layer of deprenyl on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the deprenyl to form a heated vapor of the deprenyl, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the deprenyl comprising less than 5% deprenyl degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (30, 31)
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32. A method of producing ropinerole in an aerosol form comprising:
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a. heating a thin layer of ropinerole on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the ropinerole to form a heated vapor of the ropinerole, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the ropinerole comprising less than 5% ropinerole degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (33, 34)
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Specification