Multilayer coating for releasing biologically-active agents and method of making
First Claim
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1. An article capable of affecting a biological process, the article comprising:
- a substrate having a surface;
an erodible layer positioned over the surface of the substrate and comprising a release material and a first biologically-active agent releasable from the erodible layer when exposed to an aqueous fluid; and
a polymer layer comprising a polymer and a second biologically-active agent releasable from the polymer layer when exposed to the aqueous fluid.
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Abstract
A composition for use with healthcare products such as medical device includes one or more biologically-active agents for release into bodily fluids. The composition can be applied to a substrate to form an erodible layer and a polymer layer. Biologically-active agent(s) are releasable from the erodible layer and the polymer layer when exposed to aqueous fluids.
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Citations
30 Claims
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1. An article capable of affecting a biological process, the article comprising:
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a substrate having a surface;
an erodible layer positioned over the surface of the substrate and comprising a release material and a first biologically-active agent releasable from the erodible layer when exposed to an aqueous fluid; and
a polymer layer comprising a polymer and a second biologically-active agent releasable from the polymer layer when exposed to the aqueous fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A composition for affecting a biological process, the composition comprising:
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a release material that disintegrates in an aqueous fluid;
a first biologically-active agent incorporated within the release material and releasable through disintegration of the release material;
a polymer matrix; and
a second-biologically active agent incorporated within the polymer matrix and releasable from the polymer matrix upon exposure to an aqueous fluid. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for coating a substrate, the method comprising:
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providing functional groups on a surface of the substrate;
depositing a base layer on the functionalized surface, the base layer comprising;
a release material; and
a first biologically-active agent; and
forming a polymer layer over the base layer, the polymer layer including a second biologically-active agent that is releasable from the polymer layer when exposed to an aqueous fluid. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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Specification