Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders

• US 20060217304A1
• Filed: 12/23/2005
• Published: 09/28/2006
• Est. Priority Date: 02/16/2001
• Status: Active Grant

• Current Assignee: ConjuChem LLC (Colabor Group, Inc.)
• Original Assignee: Advanced Diagnostics USA Corporation (Advanced Diagnostics)
• Inventors: Robitaille, Martin, Bridon, Dominique P., Thibaudeau, Karen, Leger, Roger, Carette, Julie, Boudjellab, Nissab
• Granted Patent: US 7,737,251 B2
• Time in Patent Office: Days
• US Class Current: 530/308
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 47/643 Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: C07K 14/605 Glucagons
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular, this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.

Claims

1. A gastrointestinal tissue growth promoter derivative comprising:

a GLP-2 peptide or an analog or fragment thereof having gastrointestinal tissue growth promoting activity; and

a reactive entity coupled to the peptide,

the derivative being capable of covalently binding in vivo with a functionality on a blood component.

2-19. -19. (canceled)