Method and apparatus for noninvasive targeting
First Claim
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1. A method for noninvasively determining an analyte property of a tissue sample, comprising the steps of:
- collecting a feedback targeting signal with a targeting system;
adjusting an optical measuring system to enhance sampling of at least a tissue layer, said tissue layer having an analyte concentration exceeding an average concentration of said analyte in all of said tissue sample, wherein said step of adjusting uses said feedback targeting signal;
noninvasively collecting at least one spectrum of said tissue sample using said adjusted optical measuring system; and
chemometrically determining said analyte property from said at least one spectrum.
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Abstract
The invention relates to noninvasive sampling. In one embodiment, the invention relates to a sample probe interface method and apparatus for targeting a tissue depth and/or pathlength that is used in conjunction with a noninvasive analyzer to control spectral variation. In a second embodiment, a signal from a sample or target probe of a tissue feature or volume is used in positioning a portion of a measuring system relative to the sample. The system is optionally used in conjunction with a targeting system used to control the sampling location of the measuring system.
139 Citations
20 Claims
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1. A method for noninvasively determining an analyte property of a tissue sample, comprising the steps of:
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collecting a feedback targeting signal with a targeting system;
adjusting an optical measuring system to enhance sampling of at least a tissue layer, said tissue layer having an analyte concentration exceeding an average concentration of said analyte in all of said tissue sample, wherein said step of adjusting uses said feedback targeting signal;
noninvasively collecting at least one spectrum of said tissue sample using said adjusted optical measuring system; and
chemometrically determining said analyte property from said at least one spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for noninvasively determining glucose concentration, comprising:
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a spectroscopic analyzer comprising a targeting system and a measuring system;
means for collecting a feedback signal of a skin tissue with said targeting system;
means for adjusting said measurement system to enhance targeting of an internal tissue layer;
means for collecting a second signal representative of at least said tissue layer using said adjusted measurement system; and
a chemometrics module for deriving said glucose concentration from said second signal. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification