Thermal hemostasis and/or coagulation of tissue

• US 20060217707A1
• Filed: 01/18/2006
• Published: 09/28/2006
• Est. Priority Date: 08/21/2002
• Status: Active Grant

• Current Assignee: S.D.M.H. Pty., Ltd.
• Original Assignee: S.D.M.H. Pty., Ltd.
• Inventors: Daniel, Steven A., Morris, David L.
• Granted Patent: US 8,986,297 B2
• Time in Patent Office: Days
• US Class Current: 606/50
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/143 multiple needles

Abstract

Energy delivery systems and methods are provided for use in biological tissue. The energy delivery system includes an energy source and an electrode array. The electrode array includes bipolar electrodes positioned so a first spacing between a pair of adjacent electrodes is different relative to a second spacing between at least one other pair of adjacent electrodes. The electrode array and the energy source are coupled and configured to generate uniform energy density in target tissue according to impedance of the target tissue.

Claims

1. A system comprising:

an energy source; and

an electrode array comprising bipolar electrodes positioned so a first spacing between a pair of adjacent electrodes is different relative to a second spacing between at least one other pair of adjacent electrodes, wherein the electrode array and the energy source are coupled and configured to generate uniform energy density in target tissue in response to impedance of the target tissue.

2. The system of claim 1, wherein the first spacing includes a first spacing among central electrodes of the electrode array that is relatively larger than a second spacing between at least one pair of peripheral electrodes of the electrode array.

3. The system of claim 1, wherein the impedance of the target tissue is determined using a plurality of impedance measurements and controlled through comparison to at least one pre-specified impedance threshold.

4. The system of claim 1, wherein the energy source generates a wave form that is critically damped, wherein at least one damping parameter of the wave form is determined using at least one property of the target tissue.

5. The system of claim 1, wherein the energy source generates a modulated wave form, wherein at least one modulation parameter of the modulated wave form is determined using at least one property of the target tissue.

6. The system of claim 1, wherein at least one electrode of the electrode array is configured as a sensor, wherein the impedance is determined using a change in at least one property of the target tissue as determined from information of the sensor.

7. The system of claim 1, wherein the electrode array generates controlled hemostasis in the target tissue.

8. The system of claim 1, wherein generating uniform energy density in target tissue in response to impedance includes controlling the energy delivery in accordance with impedance, wherein controlling comprises:

setting an initial impedance level according to a type of the target tissue;

measuring a first impedance of the target tissue;

initiating the energy delivery to the target tissue when the first impedance is greater than the initial impedance level, wherein initiating the energy delivery includes energy delivery at a first level that is determined according to the initial impedance level.

9. The system of claim 8, wherein controlling comprises:

measuring a second impedance of the target tissue;

comparing the second impedance to the first impedance.

10. The system of claim 9, wherein controlling comprises increasing the energy delivery to a second level when the comparing indicates a relatively steady impedance of the target tissue.

11. The system of claim 9, wherein controlling comprises reducing the energy delivery to a third level when the comparing indicates a relatively increasing impedance of the target tissue.

12. The system of claim 11, wherein controlling comprises increasing the energy delivery at a first rate to a fourth level.

13. The system of claim 11, wherein controlling comprises maintaining the energy delivery at a present level when the comparing indicates a relatively decreasing impedance of the target tissue.

14. The system of claim 13, wherein controlling comprises:

measuring a third impedance of the target tissue;

comparing the third impedance to at least one previously measured impedance.

15. The system of claim 14, wherein controlling comprises maintaining the energy delivery at a present level when the comparing indicates a relatively decreasing impedance of the target tissue.

16. The system of claim 14, wherein controlling comprises increasing the energy delivery to a fifth level when the comparing indicates a relatively steady impedance of the target tissue.

17. The system of claim 16, wherein controlling comprises determining a state of cycle completion when the comparing indicates a relatively increasing impedance of the target tissue.

18. The system of claim 17, wherein controlling comprises terminating energy delivery to the target tissue when the state of cycle completion is complete and the third impedance exceeds a final impedance level.

19. The system of claim 17, wherein controlling comprises:

measuring a fourth impedance of the target tissue;

comparing the fourth impedance to one or more of a previously measured impedance and increasing the energy delivery to a sixth level when the state of cycle completion is complete and the fourth impedance is relatively steady.

20. The system of claim 17, wherein controlling comprises:

determining a rate at which the relatively increasing impedance is increasing;

comparing the rate to a first increase rate.

21. The system of claim 20, wherein controlling comprises, when the rate is less than the first increase rate:

measuring a fifth impedance of the target tissue;

comparing the fifth impedance to one or more of a previously measured impedance and increasing the energy delivery to a seventh level when the state of cycle completion is complete and the fifth impedance is relatively steady.

22. The system of claim 20, wherein controlling comprises comparing the rate to a second increase rate when the rate is greater than the first increase rate.

23. The system of claim 22, wherein controlling comprises reducing the energy delivery to an eighth level when the rate is greater than the second increase rate.

24. The system of claim 23, wherein controlling comprises increasing the energy delivery at a second rate to a ninth level.

25. The system of claim 22, wherein controlling comprises reducing the energy delivery to a tenth level when the rate is less than the second increase rate.

26. A system comprising:

an energy source; and

an electrode array comprising bipolar electrodes positioned so a first spacing between a first pair of electrodes is different relative to a second spacing between a second pair of electrodes, wherein the electrode array and the energy source are coupled and configured to generate uniform energy density in target tissue in response to impedance of the target tissue.

27. The system of claim 26, wherein the first spacing includes a first spacing among central electrodes of the electrode array that is relatively larger than the second spacing between at least one pair of peripheral electrodes of the electrode array.

28. The system of claim 26, wherein generating uniform energy density in target tissue in response to impedance includes controlling the energy delivery in accordance with impedance, wherein controlling comprises:

setting an initial impedance level according to a type of the target tissue;

measuring an impedance of the target tissue;

initiating the energy delivery to the target tissue, wherein initiating the energy delivery includes energy delivery at a first level that is determined according to the initial impedance level.

29. The system of claim 28, wherein controlling further comprises increasing the energy delivery to a second level when the impedance is relatively steady, and reducing the energy delivery to a third level and then increasing the energy delivery at a first rate to a fourth level when the impedance is relatively increasing.

30. The system of claim 29, wherein controlling comprises maintaining the energy delivery at a present level when the impedance is relatively decreasing.

31. The system of claim 30, wherein controlling comprises further increasing the energy delivery to a fifth level when the impedance is relatively steady.

32. The system of claim 31, wherein controlling comprises determining a state of cycle completion when the impedance is relatively increasing.

33. The system of claim 32, wherein controlling comprises terminating energy delivery to the target tissue when the state of cycle completion is complete and the impedance exceeds a final impedance level, and further increasing the energy delivery to a sixth level when the state of cycle completion is complete and the impedance is relatively steady.

34. The system of claim 32, wherein controlling comprises further increasing the energy delivery to a seventh level when the state of cycle completion is complete, a rate at which the impedance is increasing is less than a first increase rate, and the impedance remains relatively steady.

35. The system of claim 32, wherein controlling comprises reducing the energy delivery to an eighth level when the rate at which the impedance is increasing is greater than a second increase rate, and then further increasing the energy delivery at a second rate to a ninth level.

36. A method for controlling hemostasis in target tissue, comprising:

configuring an array of bipolar electrodes in the target tissue so a first spacing between a pair of adjacent electrodes is different relative to a second spacing between at least one other pair of adjacent electrodes;

delivering energy to the target tissue via the array; and

controlling the delivering according to impedance of the target tissue to generate uniform energy density in the target tissue.

37. The method of claim 36, wherein configuring includes positioning each electrode of the electrode array at a selected depth in the target tissue.

38. The method of claim 36, further comprising generating at least one plane of coagulated tissue in the target tissue.

39. The method of claim 36, wherein the first spacing includes a first spacing among central electrodes of the electrode array that is relatively larger than a second spacing between at least one pair of peripheral electrodes of the electrode array.

40. The method of claim 36, wherein the delivering includes generating a wave form that is critically damped, wherein at least one damping parameter of the wave form is determined using at least one property of the target tissue.

41. The method of claim 36, wherein the delivering includes generating a modulated wave form, wherein at least one modulation parameter of the modulated wave form is determined using at least one property of the target tissue.

42. The method of claim 36, wherein controlling the delivering according to impedance includes controlling the delivering in accordance with impedance, wherein controlling comprises:

setting an initial impedance level according to a type of the target tissue;

measuring a first impedance of the target tissue;

initiating the energy delivery to the target tissue when the first impedance is greater than the initial impedance level, wherein initiating the energy delivery includes energy delivery at a first level that is determined according to the initial impedance level.

43. The method of claim 42, wherein controlling comprises:

measuring a second impedance of the target tissue;

comparing the second impedance to the first impedance.

44. The method of claim 43, wherein controlling comprises increasing energy delivery to a second level when the comparing indicates a relatively steady impedance of the target tissue.

45. The method of claim 43, wherein controlling comprises reducing energy delivery to a third level when the comparing indicates a relatively increasing impedance of the target tissue.

46. The method of claim 45, wherein controlling comprises increasing energy delivery at a first rate to a fourth level.

47. The method of claim 45, wherein controlling comprises maintaining energy delivery at a present level when the comparing indicates a relatively decreasing impedance of the target tissue.

48. The method of claim 47, wherein controlling comprises:

measuring a third impedance of the target tissue;

comparing the third impedance to at least one previously measured impedance.

49. The method of claim 48, wherein controlling comprises maintaining energy delivery at a present level when the comparing indicates a relatively decreasing impedance of the target tissue.

50. The method of claim 48, wherein controlling comprises increasing energy delivery to a fifth level when the comparing indicates a relatively steady impedance of the target tissue.

51. The method of claim 50, wherein controlling comprises determining a state of cycle completion when the comparing indicates a relatively increasing impedance of the target tissue.

52. The method of claim 51, wherein controlling comprises terminating energy delivery to the target tissue when the state of cycle completion is complete and the third impedance exceeds a final impedance level.

53. The method of claim 51, wherein controlling comprises:

measuring a fourth impedance of the target tissue;

comparing the fourth impedance to one or more of a previously measured impedance and increasing energy delivery to a sixth level when the state of cycle completion is complete and the fourth impedance is relatively steady.

54. The method of claim 51, wherein controlling comprises:

determining a rate at which the relatively increasing impedance is increasing;

comparing the rate to a first increase rate.

55. The method of claim 54, wherein controlling comprises, when the rate is less than the first increase rate:

measuring a fifth impedance of the target tissue;

comparing the fifth impedance to one or more of a previously measured impedance and increasing energy delivery to a seventh level when the state of cycle completion is complete and the fifth impedance is relatively steady.

56. The method of claim 54, wherein controlling comprises comparing the rate to a second increase rate when the rate is greater than the first increase rate.

57. The method of claim 56, wherein controlling comprises reducing energy delivery to an eighth level when the rate is greater than the second increase rate.

58. The method of claim 57, wherein controlling comprises increasing energy delivery at a second rate to a ninth level.

59. The method of claim 56, wherein controlling comprises reducing energy delivery to a tenth level when the rate is less than the second increase rate.